Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2- (1,3,4-thiadiazolyl) ]methylenediamine
Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M.
Il Farmaco; Edizione Scientifica 41(9): 713-721
1986
ISSN/ISBN: 0430-0920 PMID: 3780959 Document Number: 282160
Some 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylendiamines were synthetized and tested against lymphocytic murine leukemia P 388. Compounds (I)-(III), (VIII)-(XII) and (XVIII)-(XIX) showed significant by prolongation the survival time of tumor-bearing mice (T/C% 129-194).
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