Synthesis and antileukemic activity of 1-[ (quinolizidinylalkyl) amino]4/7-R-thioxanthen-9-ones
Boido Canu, C.; Iusco, G.; Boido, V.; Sparatore, F.; Sparatore, A.
Farmaco 44(11): 1069-1082
1989
ISSN/ISBN: 0014-827X PMID: 2701964 Document Number: 329464
Fifteen 1-(quinolizidinylalkyl)amino derivatives of thioxanthenone bearing different substituents on position 4 and 7 were prepared and tested in mice against lymphocytic leukemia P 388. These compounds were inactive or displayed only borderline activity (compounds 1, 10, 15).
Document emailed within 1 workday
Related Documents
Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M. 1986: Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine Il Farmaco; Edizione Scientifica 41(9): 713-721Mosti, L.; Schenone, P.; Menozzi, G.; Romussi, G.; Baccichetti, F.; Carlassare, F.; Bordin, F. 1984: Synthesis and photobiological activity of N,N-disubstituted 4-amino-3-chloro-2H-thieno[2,3-h]-1-benzopyran-2-ones, 7-thioisosteres of 4-amino-3-chloroangelicins Il Farmaco; Edizione Scientifica 39(2): 81-94
Oelschläger, H.; Dünges, W.; Götze, G. 1972: Synthesis of ortho-aryloxymethylated omega-amino-alkyl-benzole with local-anesthetic activity. 8. Synthesis of new compounds with local-anesthetic activity Arzneimittel-Forschung 22(6): 1013-1019
Chimirri, A.; Gitto, R.; Grasso, S.; Monforte, A.M.; Zappalà, M. 1994: Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes Farmaco 49(10): 649-651
Lettieri, G.; Brancaccio, G.; Larizza, A. 1981: Synthesis and pharmacological activity of 4-((7-chloro-quinolyl)amino)acylamides Bollettino Chimico Farmaceutico 120(5): 308-310
Vicini, P.; Amoretti, L.; Chiavarini, M.; Impicciatore, M. 1990: Synthesis and local anesthetic activity of alkylaminoacyl derivatives of 3-amino-1,2-benzisothiazoles Farmaco 45(9): 933-943
Odasso, G.; Winters, G.; Schiatti, P.; Selva, D. 1983: Cyclic hydrazides. V - synthesis and antiinflammatory activity of derivatives of the 2-amino-1,4-dihydroisoquinolin-3(2H)-one Il Farmaco; Edizione Scientifica 28(3): 199-204
Ubukata, M.; Osada, H.; Isono, K. 1985: Synthesis and biological activity of nucleoside antibiotics, ascamycin and its amino acid analogs Nucleic Acids Symposium Series 16: 81-83
Wu, K.M.; Zhang, M.Y.; Fang, Z.; Huang, L. 1985: Potential antileukemic agents, synthesis of derivatives of indirubin, indigo, and isoindigotin Yao Xue Xue Bao 20(11): 821-826
Caliendo, G.; Fiorino, F.; Grieco, P.; Perissutti, E.; De Luca, S.; Giuliano, A.; Santelli, G.; Califano, D.; Severino, B.; Santagada, V. 1999: Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids Farmaco 54(11-12): 785-790
Romussi, G.; Parodi, B.; Bignardi, G.; Menozzi, G.; Schenone, P. 1986: Reaction of N,N-disubstituted alpha-aminomethyleneketones with tosyl isocyanate. Synthesis of amino-disubstituted 2-acyl-3-amino-N-tosylpropenamides, N,N-(3-amino-1-alkyl-2-propenylidene) and N,N-[2-(aminomethylene)cyclohexylidene]tosylamides Il Farmaco; Edizione Scientifica 41(7): 539-547
Abd El-Salam, O.I.; Abou El Ella, D.A.; Ismail, N.S.M.; Abdullah, M. 2009: Synthesis, docking studies and anti-inflammatory activity of some 2-amino-5,6,7,8-tetrahydroquinoline-3-carbonitriles and related compounds Die Pharmazie 64(3): 147-155
Gordon, S.; Costa, L.; Incerti, M.; Manta, E.; Saldaña, J.; Domínguez, L.; Mariezcurrena, R.; Suescun, L. 1997: Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives Farmaco 52(10): 603-608
Pedrazzoli, A.; Dall'asta, L.; Maffi, G.; Giudice, A.; Ferrero, E. 1976: Parsalmide: a new anti-inflammatory agent. I. Synthesis and preliminary pharmacological activity of a series of 2-alkyloxy-5-amino-N-alkylbenzamides Bollettino Chimico Farmaceutico 115(2): 125-134
Pellicciari, R.; Natalini, B.; Marinozzi, M.; Sadeghpour, B.M.; Cordi, A.A.; Lanthorn, T.H.; Hood, W.F.; Monahan, J.B. 1991: Synthesis, absolute configuration and activity at N-methyl-D-aspartic acid (NMDA) receptor of the four D-2-amino-4,5-methano-adipate diastereoisomers Farmaco 46(11): 1243-1264
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Veretennikova, N.L.; Lebedeva, M.N.; Pereverzeva, E.V.; Lychko, N.D. 1995: The search for new antiparasitic agents. 14. the synthesis, acute toxicity and anthelmintic activity of N-(3,5-dibromobenzo-2,1,3-thiadiazolyl-4)-2-[(4-ch lorophenylsulfonyl)amino]-5-bromobenzamide Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 30-32
Koutsourea, A.I.; Fousteris, M.A.; Arsenou, E.S.; Papageorgiou, A.; Pairas, G.N.; Nikolaropoulos, S.S. 2008: Synthesis, in vivo antileukemic evaluation and comparative study of novel 5alpha-7-keto steroidal esters of chlorambucil and its active metabolite In Vivo 22(3): 345-352
Fousteris, M.A.; Koutsourea, A.I.; Arsenou, E.S.; Papageorgiou, A.; Mourelato, D.; Nikolaropoulos, S.S. 2002: Antileukemic and cytogenetic effects of modified and non-modified esteric steroidal derivatives of 4-methyl-3-bis(2-chloroethyl)amino benzoic acid (4-Me-CABA) Anticancer Research 22(4): 2293-2299
Gao, Z.L.; Rao, E.C. 1993: Synthesis of formyl (acetyl) amino acid and dipeptide derivatives of amino ketones Yao Xue Xue Bao 28(10): 744-757
Tian, S.L.; Zhao, S.W.; Zhu, A.T.; Fang, Y.; Li, K.Q. 1993: Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin Yao Xue Xue Bao 28(11): 870-875