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Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin

Tian, S.L.; Zhao, S.W.; Zhu, A.T.; Fang, Y.; Li, K.Q.

Yao Xue Xue Bao 28(11): 870-875

1993

ISSN/ISBN: 0513-4870
PMID: 8010005
Document Number: 414960
In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-oxo-7-oxabicyclo (2.2.1) heptane-2,3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 mu-mol/ml).

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