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Synthesis and anti-HIV activity of some non-nucleoside 2,3-disubstituted quinazoline derivatives (Part-V)

Desai, N.C.; Undavia, N.K.; Trivedi, P.B.; Dave, D.; Vyas, G.D.

Indian Journal of Experimental Biology 36(12): 1280-1283

1998

ISSN/ISBN: 0019-5189
PMID: 10093513
Document Number: 484586
Several [2-phenyl-4(3H)-oxo-3-quinazolinylamino]-N-substituted- arylacetamides (1a-j) have been synthesized and tested at the National Cancer Institute, Bethesda, Maryland, USA, for their anti-HIV activity against susceptible human host cells (CEM cell line) over a wide range of concentrations (6.35 x 10(-8) to 2.00 x 10(-4) M). The highest protection observed is 45.67%. The structures of these compounds have been established on the basis of elemental analysis and spectral data.

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Guryn, R.; Szadowska, A.; Pakulska, W. 1994: Diazepinoquinazolines. Part II. Synthesis and pharmacological activity of some derivatives of 1,4-diazepino[2,1-b]quinazoline Acta Poloniae Pharmaceutica 51(6): 483-487
Machoń, Z.; Jasztold-Howorko, R. 1976: Synthesis of 2,4-disubstituted 5-aminopyrimidine-6-carboxylic acids derivatives part i Polish Journal of Pharmacology and Pharmacy 28(1): 61-67
Alapati, V.; Noolvi, M.N.; Manjula, S.N.; Pallavi, K.J.; Patel, H.M.; Tippeswamy, B.S.; Satyanarayana, S.V. 2012: In vivo anti-tumour activity of novel Quinazoline derivatives European Review for Medical and Pharmacological Sciences 16(13): 1753-1764
Jakóbiec, T.; Sedzimirska, B.; Zawisza, T. 1982: Hexahydrochromane derivatives. Part II. Synthesis of 4,4-disubstituted derivatives of hexahydrochromane Polish Journal of Pharmacology and Pharmacy 34(4): 257-264
Cai, Z.B.; Zhou, M.; Hu, W.X.; Yang, Z.Y. 2000: Synthesis and antineoplastic activity of N,N'-disubstituted phenyl-3,6-dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide derivatives Yao Xue Xue Bao 35(10): 793-796
Mcelhinney, R.S.; Mccormick, J.E.; Bibby, M.C.; Double, J.A.; Atassi, G.; Dumont, P.; Pratesi, G.; Radacic, M. 1989: Nucleoside analogues. 9. Seco-nucleoside analogues of some 5-fluorouracil/nitrosourea molecular combinations having uracil as base: synthesis and anti-tumour activity Anti-Cancer Drug Design 4(3): 191-207
Schulz, U.; Freitag, M.; Schmidt, K.; Witetschek, M.; Polzin, M.; Morgenstern, O. 2014: Synthesis and structure elucidation of 2,3,5,6,7,8-hexahydro-1 H-[1,2,4]triazolo[1,2-a]pyridazine-1-thione, 3,3-disubstituted and 2-substituted derivatives and evaluation of their inhibitory activity against inducible nitric oxide synthase Die Pharmazie 69(10): 731-744
Sansebastiano, L.; Mosti, L.; Menozzi, G.; Schenone, P.; Muratore, O.; Petta, A.; Debbia, E.; Schito, A.P.; Schito, G.C. 1993: Synthesis, antiviral (HSV-1) and antimycotic activities of ethyl or methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,4-disubstituted 5-pyrimidinecarboxylic acids and 2,4-disubstituted pyrimidines Farmaco 48(3): 335-355
Tian, S.L.; Zhao, S.W.; Zhu, A.T.; Fang, Y.; Li, K.Q. 1993: Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin Yao Xue Xue Bao 28(11): 870-875
Yamamoto, H.; Saito, C.; Inaba, S.; Awata, H.; Yamamoto, M. 1973: Novel quinazoline derivatives. II. a new anti-inflammatory agent, SL-512 Arzneimittel-Forschung 23(9): 1266-1271
Sridhar, S.K.; Pandeya, S.N.; De Clercq, E. 2001: Synthesis and anti-HIV activity of some isatin derivatives Bollettino Chimico Farmaceutico 140(5): 302-305
Wang, X.-J.; Liu, J.-L.; Wang, J.-K. 2012: Synthesis and anti-tumor activity of paeonol and its derivatives Yao Xue Xue Bao 47(1): 72-76
Giori, P.; Guarneri, M.; Mazzotta, D.; Vertuani, G.; Branca, C. 1979: Synthesis and anti-fungal activity of 5-aminopyrazole derivatives Il Farmaco; Edizione Scientifica 34(4): 277-283
Zhang, X.P.; Shen, D.F.; Zhang, X.J.; Chen, L.; Dai, Z.R.; Shu, K.Q. 1981: Studies on antimalarials. VI. Synthesis and antimalarial activities of some 2, 4-diamino-6-substituted amino sulfonyl quinazoline derivatives Yao Xue Xue Bao 16(11): 877-880
El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A. 1982: Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii Il Farmaco; Edizione Scientifica 37(7): 494-500
Lagorce, J.F.; Lakhdar, M.; Fatimi, J.; Nefaoui, S.; Raby, C. 1992: Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives Farmaco 47(12): 1477-1485
Meng, Y.-q.; Nie, H.-h.; Wang, X.-c.; Li, D.; Ge, C.-x.; Zhao, N.; Chen, H.; Cao, B. 2011: Synthesis and anti-tumor activity of oleanolic acid derivatives Yao Xue Xue Bao 46(10): 1215-1220
Meng, Y.-q.; Feng, C.-q.; Zhang, L.-f.; Zhang, M.; Zhao, N. 2015: Synthesis and anti-tumor activity of oleanolic acid derivatives Yao Xue Xue Bao 50(4): 469-474
Zhang, X.P.; Chen, G.D.; Dai, Z.R.; Ma, Z.M. 1984: Studies on antimalarials. XII. Synthesis and antimalarial activities of some derivatives of 2,4-disubstituted-6-substituted amino quinazolines Yao Xue Xue Bao 19(10): 792-795
Lyakhov, S.A.; Suveyzdis, Y.I.; Litvinova, L.A.; Andronati, S.A.; Rybalko, S.L.; Dyadyun, S.T. 2000: Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides Die Pharmazie 55(10): 733-736