Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides
Lyakhov, S.A.; Suveyzdis, Y.I.; Litvinova, L.A.; Andronati, S.A.; Rybalko, S.L.; Dyadyun, S.T.
Die Pharmazie 55(10): 733-736
2000
ISSN/ISBN: 0031-7144 PMID: 11082832 Document Number: 524079
Nine bis-acridine derivatives have been synthesized in search of structures with antiviral properties. Synthesis of target compounds was provided by a standard peptide-like coupling procedure using aliphatic diamines and protected amino acids following protective group removing and acridinylation by means of 9-methoxyacridine. Two out of nine compounds tested demonstrate high protective activity of Vero cells against HSV infection. Antiviral activity was observed only for compounds containing a pentamethylene fragment as a linker. The alanyl-containing derivative was less active than those containing valyl- and phenylalanyl. Most of synthesized compounds were less toxic than N,N'-bis-(acridinyl) hexamethylenediamine.