Synthesis of p-menthane derivatives with potential biological activity
Witkiewicz, K.; Rykowski, Z.; Machoń, Z.; Lipnicka, U.; Burak, K.
Die Pharmazie 43(2): 84-86
1988
ISSN/ISBN: 0031-7144 PMID: 3393592 Document Number: 325179
The synthesis of amino ketones and amino alcohols in p-menthane series is presented. These compounds were obtained in Mannich reaction, starting from the unsaturated ketone p-mentha-6,8-dien-2-one and its saturated analogue p-menthan-2-one. The structures of the compounds obtained were established by means of chemical transformations and elemental and spectral (IR, 1H NMR) analysis. The compounds obtained were subjected to the pharmacological investigations.