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Piperazine derivatives of benzimidazole as potential anthelmintics. Part 1: Synthesis and activity of methyl-5- (4-substituted piperazin-1-yl) benzimidazole-2-carbamates

Sánchez-Alonso, R.M.; Raviña, E.; Santana, L.; García-Mera, G.; Sanmartín, M.; Baltar, P.

Die Pharmazie 44(9): 606-607

1989

ISSN/ISBN: 0031-7144
PMID: 2608706
Document Number: 345387
A series of 5-(4-substituted piperazin-1-yl)-2-nitroanilines (4) and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (6) has been synthesized starting from 5-chloro-2-nitroaniline (3) and N-monosubstituted piperazines. Catalytic reduction of 4 with Pd/C followed by treatment with 1,3-dicarbomethoxy-S-methylisothiourea yielded the corresponding methyl-5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (6) which were for anthelmintic activity against experimental infections of Trichinella spiralis.

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