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Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii

El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A.

Il Farmaco; Edizione Scientifica 37(7): 494-500

1982

ISSN/ISBN: 0430-0920
PMID: 7128807
Document Number: 191700
3-Nitro-9-(N-phthalyl- and N-tosylaminoacyl)carbazoles (II-XI) have been synthesized by the action of 3-nitro-9H-carbazole (I) on N-phthalyl- or N-tosylamino acid in THF-Et3N medium using the DCC method. Treatment of the 3-nitro derivatives (II-XI) with Sn/HCl gave the corresponding 3-amino-9-(N-phthalyl- or N-tosylaminoacyl)carbazoles (XII-XIX). Hydrazinolysis of the N-phthalylcarbazoles derivatives (III-VII) in ethanol gave the corresponding 3-nitro-9-(aminoacyl) carbazoles (XX-XXIII). Compounds (II-XI and XXI, XXII) were found to be active against some microorganisms.

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