Cardiovascular activity of 1,2,4-benzothiadiazine-1,1-dioxide derivatives. Part 10 (3) : Dialkylamino-, pyrrolidyl- and morpholyl-alkyl-derivatives of 3-amino-1,2,4-benzothiadiazine-1,1-dioxide, 7- or 5,7-halogen substituted
Parenti, C.; Costantino, L.; Di Bella, M.; Raffa, L.; Baggio, G.G.
Die Pharmazie 43(1): 37-39
1988
ISSN/ISBN: 0031-7144 PMID: 3375300 Document Number: 318716
A series of dialkylamino, pyrrolidyl and morpholyl-alkyl-derivatives of 3-amino-1,2,4-benzothiadiazine-1,1-dioxide, 7- or 5,7-halogen substituted in the benzenoid moiety, was prepared and their cardiovascular activity studied. Most of the substances in question were capable of inducing a significant decrease in mean arterial blood pressure; some of them tended to increase pulse pressure or to cause bradycardia, an effect which was noted particularly in the case of compound 10 which reduced heart-rate by 85%. The structure/activity relationship of these substances, of the 6- and 6,7-halogen substituted isomers and of their corresponding non-substituted progenitors is examined.