Top Abstract Purchase Related
Home
>
Node
>
Subnode

Synthesis and antitumor activity of 1- or 3- (alpha-hetero substituted) alkyl-5-fluorouracil derivatives

Ozaki, S.; Nagase, T.; Ahmad, S.; Tamai, H.; Hoshi, A.; Iigo, M.

Nucleic Acids Symposium Series 18: 1-4

1987

ISSN/ISBN: 0261-3166
PMID: 3697106
Document Number: 301524
Two classes of 5-fluorouracil (5-FU) derivatives were prepared from 1,3-bis(hydroxymethyl)-5-fluorouracil (1). The first group was obtained by the direct esterification of 1 with various acids. The second one was derived by the nucleophilic substitution of N-(chloromethyl)-5-FUs, which were easily prepared by halogenation of 1, with hetero nucleophiles. The antitumor activities of the prepared compounds were examined against Leukemia L1210 and the results were compared with that of 1-hexylcarbamoyl-5-fluorouracil (HCFU, Carmofur).

Document emailed within 1 workday
Secure & encrypted payments

Mao, M.; Chen, Y.; Tian, X. 1998: Synthesis and antitumor activity of new heterocyclic 5-fluorouracil derivatives Yao Xue Xue Bao 33(5): 389-391
Ersan, S.; Nacak, S.; Acar, N.; Noyanalpan, N. 1997: Synthesis and antimicrobial activity of 1-dialkylaminomethyl- 2-(p-substituted phenyl)-5-substituted benzimidazole derivatives Arzneimittel-Forschung 47(4): 410-412
Bahekar, S.S.; Shinde, D.B. 2003: Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives Acta Pharmaceutica 53(3): 223-229
Weng, Z.Y.; Zhang, G.R. 1984: Antitumor activity of open ring analogues of ungeremine (AT-1840)--preparation of substituted N-alkyl phenanthridinium bromides by a photochemical reaction Yao Xue Xue Bao 19(1): 28-34
Bonjean, V.J.; Schunack, W. 1988: Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics Arzneimittel-Forschung 38(4): 501-507
Alunni-Bistocchi, G.; Orvietani, P.L.; Ricci, A.; Binaglia, L.; Orlando, M.; Orlando, P. 1990: Synthesis of 1-O-alkyl-2-O-methyl-glycerophospholipids with potential antitumor activity Farmaco 45(5): 499-509
Parenti, C.; Costantino, L.; Di Bella, M.; Raffa, L.; Baggio, G.G. 1988: Cardiovascular activity of 1,2,4-benzothiadiazine-1,1-dioxide derivatives. Part 10(3): Dialkylamino-, pyrrolidyl- and morpholyl-alkyl-derivatives of 3-amino-1,2,4-benzothiadiazine-1,1-dioxide, 7- or 5,7-halogen substituted Die Pharmazie 43(1): 37-39
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Kirkiacharian, S.; Alaoui, M.A.; Ouidren, M.; Gayral, P. 1996: Synthesis and antiparasitic activity of new N-alkyl derivatives of 1-(nitrophenyl)-3-(methyl-3-indolyl)-prop-2-ene-1-ones (nitroindolylchalcones) Annales Pharmaceutiques Francaises 54(6): 272-275
Huang, S.Q.; Jiang, Z.C.; Li, L.Z.; Xu, J.Y.; Yang, J. 1991: Study on porphyrins:synthesis and antitumor activity of porphyrin-fluorouracil compounds Yao Xue Xue Bao 26(6): 415-419
Moron, J.; Rautureau, M.; Huel, C.; Pierré, A.; Berthier, L.K.; Atassi, G.; Bisagni, E. 1993: Synthesis and evaluation of 4-amino-substituted 7-methoxy (and 7-hydroxy)- 11-methyl (and 5,11-dimethyl)-10H-pyrido [2,3-b] carbazoles and 4-amino- substituted 11-methyl (and 5,11-dimethyl)-10H-pyrido[3',4':4,5] pyrrolo [3,2-g] quinolines, two new series related to antitumor ellipticine derivatives Anti-Cancer Drug Design 8(6): 399-416
Grover, A.; Dwivedy, I.; Singh, A.K.; Ray, S.; Singh, M.M.; Kamboj, V.P. 1991: Synthesis and pregnancy-inhibiting activity of 7-substituted androst-5-ene derivatives Steroids 56(9): 477-480
Mailliet, P.; Segal-Bendirdjian, E.; Kozelka, J.; Barreau, M.; Baudoin, B.; Bissery, M.C.; Gontier, S.; Laoui, A.; Lavelle, F.; Le Pecq, J.B. 1995: Asymmetrically substituted ethylenediamine platinum(II) complexes as antitumor agents: synthesis and structure-activity relationships Anti-Cancer Drug Design 10(1): 51-73
Gutkowska, B.; Wasiak, J. 1984: Synthesis of various 5,5-substituted derivatives of 3-dialkylamino-alkylohydantoin with potential pharmacological activity Acta Poloniae Pharmaceutica 41(3): 307-311
Fayed, A.A.; Amr, A.E.-G.E.; Al-Omar, M.A.; Mostafa, E.E. 2014: Synthesis and antimicrobial activity of some new substituted pyrido[3',2':4,5]thieno[3,2-d]-pyrimidinone derivatives Bioorganicheskaia Khimiia 40(3): 335-340
El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A. 1982: Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii Il Farmaco; Edizione Scientifica 37(7): 494-500
Li, R.-P.; Zhou, W.-C.; Zhou, W.-L. 2006: Synthesis and antibacterial activity of (S) -5-acetylaminomethyl-3-[(4-substituted-aminomethyl) phenyl] -2-oxazolindinone derivatives Yao Xue Xue Bao 41(5): 418-425
Maczyński, M.; Jezierska, A.; Zimecki, M.ł; Ryng, S.ła. 2003: Synthesis, immunological activity and theoretical study of new 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives Acta Poloniae Pharmaceutica 60(2): 147-150
Vittorio, F.; Santagati, N.A.; Lancetta, T.; Duro, F.; Arrigo Reina, R.; Cosentino, C. 1984: Alkyl and aryl derivatives of isoquinoline. II. Synthesis and pharmacologic activity of dialkylaminoalkyl esters of 1-chloro-3-carboxy-4-methylisoquinoline and the corresponding 4-phenyl derivative Il Farmaco; Edizione Scientifica 39(3): 217-228
Wang, B.; Pan, X.-d.; Liu, H.-y.; Yang, J.; Lü, Z.-y.; Zhao, J.-h. 2006: Synthesis and antitumor activity of nitrogen-based thiocolchicine derivatives Yao Xue Xue Bao 41(11): 1057-1063