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Synthesis, immunological activity and theoretical study of new 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives

Maczyński, M.; Jezierska, A.; Zimecki, M.ł; Ryng, S.ła.

Acta Poloniae Pharmaceutica 60(2): 147-150

2003

ISSN/ISBN: 0001-6837
PMID: 13678327
Document Number: 559560
A new series of 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives was prepared and investigated. The immunological activities of the studied compounds were investigated in two murine models of the immune response to sheep erythrocytes (SRBC)--the humoral immune response and delayed type hypersensitivity (DTH). Quantum-chemical calculations were carried out using AM1, a semiempirical method for geometry optimization, estimation of descriptors values and localization of the HOMO and LUMO orbitals.

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Russo, F.; Santagati, M.; Santagati, A. 1978: Synthesis of 2-substituted derivatives of 5H-1,2,4-thiadiazolo[3,2-a] [1,3,5]triazin-5-one Il Farmaco; Edizione Scientifica 33(1): 26-39
Sváb, A.; Zikán, V.; Danĕk, J.; Spaldonová, R. 1983: 3-substituted derivatives of 5-methylisoxazole with antiparasitic effects Ceskoslovenska Farmacie 32(9-10): 316-322
Ersan, S.; Nacak, S.; Acar, N.; Noyanalpan, N. 1997: Synthesis and antimicrobial activity of 1-dialkylaminomethyl- 2-(p-substituted phenyl)-5-substituted benzimidazole derivatives Arzneimittel-Forschung 47(4): 410-412
Bahekar, S.S.; Shinde, D.B. 2003: Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives Acta Pharmaceutica 53(3): 223-229
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Grover, A.; Dwivedy, I.; Singh, A.K.; Ray, S.; Singh, M.M.; Kamboj, V.P. 1991: Synthesis and pregnancy-inhibiting activity of 7-substituted androst-5-ene derivatives Steroids 56(9): 477-480
Sztanke, K.; Tkaczyński, T. 1997: Synthesis of new derivatives of 3-[4'-(2'-aminothiazolyl)]-8-aryl-7, 8-dihydro-6H-imidazo[2,1-c] [1,2,4]triazin-4-one Acta Poloniae Pharmaceutica 54(3): 223-224
El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A. 1982: Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii Il Farmaco; Edizione Scientifica 37(7): 494-500
Fayed, A.A.; Amr, A.E.-G.E.; Al-Omar, M.A.; Mostafa, E.E. 2014: Synthesis and antimicrobial activity of some new substituted pyrido[3',2':4,5]thieno[3,2-d]-pyrimidinone derivatives Bioorganicheskaia Khimiia 40(3): 335-340
Gutkowska, B.; Wasiak, J. 1984: Synthesis of various 5,5-substituted derivatives of 3-dialkylamino-alkylohydantoin with potential pharmacological activity Acta Poloniae Pharmaceutica 41(3): 307-311
Ozaki, S.; Nagase, T.; Ahmad, S.; Tamai, H.; Hoshi, A.; Iigo, M. 1987: Synthesis and antitumor activity of 1- or 3-(alpha-hetero substituted)alkyl-5-fluorouracil derivatives Nucleic Acids Symposium Series 18: 1-4
Li, R.-P.; Zhou, W.-C.; Zhou, W.-L. 2006: Synthesis and antibacterial activity of (S) -5-acetylaminomethyl-3-[(4-substituted-aminomethyl) phenyl] -2-oxazolindinone derivatives Yao Xue Xue Bao 41(5): 418-425
Chantegrel, J.; Albuquerque, J.C.; Guarda, V.L.; Perrissin, M.; Lima, M.C.A.; Galdino, S.L.; Brandão, S.S.; Thomasson, F.; Pitta, I.R.; Luu-Duc, C. 2002: New substituted 4-thioxothiazolidin-2-one derivatives: synthesis and structural study Annales Pharmaceutiques Francaises 60(6): 403-409
Kossakowski, J.; Krawiecka, M. 2000: Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XIII. Derivatives of 1-methoxybicyclo[2.2.2]oct-5-ene-2,3-dicarboximide Acta Poloniae Pharmaceutica 57 Suppl: 53-56
Wagner, G.; Voigt, B. 1978: Synthesis of 4-substituted 1-amidino- and 6-substituted 2-amidinonaphthyl derivatives with ketone and alcohol structure Die Pharmazie 33(9): 568-572
Kossakowski, J.; Krawiecka, M. 2003: Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XXIV. Derivatives of N-hydroxy-1-methoxybicyclo[2.2.2]oct-5-ene-2,3-dicarboximide Acta Poloniae Pharmaceutica 60(3): 177-182
Zawadowski, T.; Zadrozna, A.; Rump, S.; Jakowicz, I. 1994: Synthesis of some N-substituted derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with an expected activity on central nervous system Acta Poloniae Pharmaceutica 51(6): 467-470
Kossakowski, J.; Perliński, M.ła. 2002: Synthesis of new n-substituted cyclic imides with potential anxiolytic activity. XXIII. Derivatives of 2'-chlorodibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide Acta Poloniae Pharmaceutica 59(6): 423-427
Kossakowski, J.; Jarocka, M. 2000: Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XII. Derivatives of N-hydroxy-1,4-dimethyl-dibenzo[e.h]bicyclo[2.2.2]-octane-2,3-dicarboximide Acta Poloniae Pharmaceutica 57 Suppl: 60-62
Balbi, A.; Roma, G.; Mazzei, M.; Sottofattori, E.; Cadel, S.; Schiantarelli, P. 1989: Chemistry and pharmacology of pyrane derivatives. XVII. Synthesis of substituted 2-(dialkylamino)-3-formylchromones and their tricyclic derivatives Farmaco 44(6): 565-577