Study on porphyrins:synthesis and antitumor activity of porphyrin-fluorouracil compounds
Huang, S.Q.; Jiang, Z.C.; Li, L.Z.; Xu, J.Y.; Yang, J.
Yao Xue Xue Bao 26(6): 415-419
1991
ISSN/ISBN: 0513-4870 PMID: 1789106 Document Number: 377562
Three covalently linked porphyrin-fluorouracil compounds were synthesized. Measurement using these compounds for inhibition of mice transplanted tumor growth, cytotoxicity to mice cancer cells and the mice ear index under exposure to a light was performed. The results indicated that all these compounds were phototoxic to the cancer cells, and compound 1 was the most effective among them.
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