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Synthesis of new 1-phenyl-6H-pyrido[4,3-b]carbazole derivatives with potential cytostatic activity

Tylińska, B.; Jasztold-Howorko, R.; Mastalarz, H.; Szczaurska-Nowak, K.; Materek, P.; Wietrzyk, J.

Acta Poloniae Pharmaceutica 68(1): 31-37

2011

ISSN/ISBN: 0001-6837
PMID: 21485699
Document Number: 655416
A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A549) and human colon cancer (HT29) cell lines. One particular compound 6f exhibited over 20 times better activity against L1210 tumor cell line than the reference ellipticine.

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