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Synthesis of 6-[ (4-imidazol-1-yl) -phenyl]-4-phenyl 4,5-dihydro-2H-pyridazin-3-one: a potential blood platelet aggregation inhibitor

Coudert, P.; Rubat, C.; Couquelet, J.; Tronche, P.

Journal de Pharmacie de Belgique 45(3): 191-195

1990

ISSN/ISBN: 0047-2166
PMID: 2401951
Document Number: 364578
A new 4,5 diaryl pyridazin-3-one, an analogue of imazodan and Cl-930 was prepared starting from conveniently available chalcone. The resulting derivative was tested in order to determine the area of pharmacological activity. This compound was devoid of positive inotropic effects but showed an important inhibition of PAF-acether induced blood platelet aggregation in vitro with a Cl50 value of 3,4 microM. Ex vivo, anti-aggregating effect against PAF-acether was less important with a DE50 value of 63 mg/kg per os.

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