Synthesis and biological activity of 5-phenyl-1,3,4-benzotriazepines. 14. the reactions of 2-thioxo-5-phenyl-1,3,4-benzotriazepines
Morgenstern, O.; Besch, A.; Richter, P.
Die Pharmazie 43(11): 760-761
1988
ISSN/ISBN: 0031-7144 PMID: 3247361 Document Number: 318018
The interaction of 2-aminoethanol and 2-thioxo-5-phenyl-1,3,4-benzotriazepines in abs. dioxane under refluxing conditions was investigated. Depending on the substitution of the triazepine ring several products are formed. The S-N-exchange to form the corresponding 2-(2-hydroxyethyl)-amino derivatives only takes place if the nitrogen atoms of the heterocycle are unsubstituted.
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