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3,5-diphenyl-1H-pyrazole derivatives. XI. N-aryl-5 (3) -phenyl-4- (3,5- diphenyl-1-pyrazolyl) -3 (5) -pyrazole amines, 5-substituted 4,5-dihydro-3-phenyl-4- (3,5-diphenyl-1-pyrazolyl) -1H-pyrazoles and 2,6-disubstituted 1,6-dihydro-4- phenyl-5- (3,5-diphenyl-1-pyrazolyl) pyrimidines with antipyretic, antiinflammatory and other activities

Bruno, O.; Ranise, A.; Bondavalli, F.; Schenone, P.; D'Amico, M.; Filippelli, A.; Filippelli, W.; Rossi, F.

Farmaco 48(7): 949-966

1993

ISSN/ISBN: 0014-827X
PMID: 8397678
Document Number: 406858
The synthesis of N-aryl-5(3)-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-3(5)- pyrazoleamines 3 by reaction of some N-aryl-3-oxo-3-phenyl-2-(3,5-diphenyl-1- pyrazolyl)propanecarbothioamides with hydrazine is described. Also prepared were 4,5-dihydro-3-phenyl-4-(3,5-diphenyl-1-pyrazolyl)-1H-pyrazoles 6 and 1,6-dihydro-4-phenyl-5-(3,5-diphenyl-1-pyrazolyl)pyrimidines 7 by reaction of 1-phenyl-2-(3,5-diphenyl-1-pyrazolyl)-2-buten-1-one with hydrazine or guanidine and benzamidine, respectively. Some compounds 3, 6 and 7 showed remarkable antipyretic, antiinflammatory and in vitro platelet antiaggregating activities, as well as weak analgesic, antiarrhythmic, hypotensive and local anesthetic activities in rats and mice.

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