Synthesis of 1- (3-amino-2-hydroksypropyl) -4-phenyl-1,2,4-triazolin-5-one and 1- (3-amino-2-hydroksypropyl) -3,4-diphenyl-1,2,4-triazolin-5-one derivatives
Dobosz, M.; Struga, M.; Chodkowska, A.; Jagiełło-Wójtowicz, E.
Acta Poloniae Pharmaceutica 57(5): 363-368
2000
ISSN/ISBN: 0001-6837 PMID: 11126027 Document Number: 512614
In the reaction of 4-phenyl-1,2,4-triazolin-5-one [Ia] and 3,4-diphenyl-1,2,4-triazolin-5-one [Ib] with 1-chloro-2,3-epoksypropane, the respective derivatives of 1-(2,3-epoksypropane)-4-phenyl-1,2,4-triazolin-5-one [IIa] and 1-(2,3-epoksypropane)-3,4-diphenyl-1,2,4-triazolin-5-one [IIb] were obtained. Then these compounds were converted into the corresponding aminoalkanol derivatives of 1,2,4-triazolin-5-one [IIIa, b-VIIIa, b] in reaction with secondary amines. The new compounds affected significantly the central nervous system of mice.