Studies on the antibacterial action of novel gem-diphenyl-spiro-cyclopropano- oxazolones and 2-aryl (alkyl) -4-ylidene-oxazol-5-ones
Lalitha, N.; Annapurna, J.; Iyengar, D.S.; Bhalerao, U.T.
Arzneimittel-Forschung 41(8): 827-830
1991
ISSN/ISBN: 0004-4172 PMID: 1781805 Document Number: 380768
The preparation and in vitro antibacterial activity of a novel series of gem-diphenyl-spiro-cyclopropano-oxazolones (cis-1,2,2,5-tetraphenyl 6-oxa-4-azaspiro[2.4]hept-4-en-7-one) are described. The overall activity of these compounds was higher than that of the 2-aryl(alkyl)4-ylidene-oxazol-5-ones (azlactones). The gem-diphenyl-spiro-cyclopropano-oxazolones 1-4 have emerged as the most potent derivatives when tested against bacteria.
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