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Synthesis of new pyrido- (3',2':4,5) -thieno- (3,2-d) -1,2,3-triazine derivatives as antianaphylactics

Wagner, G.; Leistner, S.; Vieweg, H.; Krasselt, U.; Prantz, J.

Die Pharmazie 48(7): 514-518

1993

ISSN/ISBN: 0031-7144
PMID: 8415848
Document Number: 418523
Some new pyrido[3',2':4,5]thieno[3,2-d]1,2,3-triazine-4(3H)-ones (C) were synthesized from 2-thioxo-1,2-dihydro-3-carbonitriles (A) via the 3-amino-thieno[2,3-b]pyridine-2-carboxamides (B). Substances of structure A were converted to 3-amino-thieno[2,3-b]pyridine-2-carbonitriles (G) which yielded the desired 4-amino substituted compounds I via the tricyclic 4-chloro-pyrido[3',2':4:5]thieno[3,2-d]1,2,3-triazines (H) by the reaction with N-nucleophiles. Some of the investigated compounds showed a respectable antianaphylactic activity.

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