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Synthesis and analgetic and antiinflammatory activity of derivatives of 3- (1H-benzimidazole-2) propanoic acid

Kuźmierkiewicz, W.; Foks, H.; Hać, E.; Strzałkowska-Grad, H.

Die Pharmazie 40(7): 462-464

1985

ISSN/ISBN: 0031-7144
PMID: 3876573
Document Number: 265080
Condensation reactions of 3-(1H-benzimidazole-2)propanoic acid (procodazol) with aromatic aldehydes were carried out resulting in lactam and acid derivatives. Basing on the spectral studies (MS, NMR) it was found that in the reaction the hydrogen atoms of the 3-methylene group of procodazol take part. 3-[2'-Acetoxyphenyl)methylene]-2,3-dihydro-1 H-pyrrole[1,2-a]benzimidazol-1-one (3c) was found to possess some analgetic properties.

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