Synthesis and potential antimycotic activity of 4-substituted-3- (thiophene-2-yl-methyl) -Delta2-1,2,4-triazoline-5-thiones
Wujec, M.; Pitucha, M.; Dobosz, M.; Kosikowska, U.; Malm, A.
Acta Pharmaceutica 54(3): 251-260
2004
ISSN/ISBN: 1330-0075 PMID: 15610621 Document Number: 568486
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.
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