Synthesis and antibacterial as well as antineoplastic activities of 2,4-diamino-5-methyl-6- (N-methyl-substituted benzyl) aminoquinazolines
Meng, X.Y.; Zhang, X.P.; Chen, X.H.; Yu, A.Z.
Yao Xue Xue Bao 26(5): 383-386
1991
ISSN/ISBN: 0513-4870 PMID: 1957691 Document Number: 370875
This paper reports four methods for the synthesis of 2,4-diamino-5-methyl-6-(N-methyl-substituted benzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done.
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