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Synthesis of some bergapten and ammajin derivatives with potential antibacterial activity

El-Sharief, A.M.; Ammar, Y.A.; El-Fatah, Y.A.; Ketcham, R.

Die Pharmazie 39(11): 745-747

1984

ISSN/ISBN: 0031-7144
PMID: 6531376
Document Number: 238402
The reaction of bergapten and ammajin with chlorosulfonic acid i shown to give the sulfonyl chlorides 1 and 11 which react with aliphatic, aromatic, and heterocyclic amines to give the corresponding sulfonamides. Phenols also react with 1 and 11 to give the sulfonate esters 5 and 15. Interaction of bergapten with phosphorous(V)sulfide gave the thione 7 which on reaction with amines gave 9. The antibacterial activity of the products is reported.

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