Synthesis and biological activity of hydrophosphoryl derivatives of amphotericin B
Belakhov, V.V.; Shenin, I.D.; Arabiĭskiĭ, R.A.; Shtil'bans, E.B.
Antibiotiki i Khimioterapiia 41(7-8): 4-8
1996
ISSN/ISBN: 0235-2990 PMID: 8999761 Document Number: 466089
Reactions of amphotericin B, a polyenic macrolide antibiotic, with aromatic aldehydes and H-3PO-2 resulted in formation of its now hydrophosphoryl derivatives. Physico-chemical and biological properties of the compounds were investigated. The biological studies showed that the hydrophosphoryl derivatives of amphotericin B were low toxic and had antifungal and antiviral activities.
Document emailed within 1 workday
Related Documents
Kornicka, A.; Hudson, A.L.; Bednarski, P.J. 2009: Synthesis and biological activity of some 2-imidazolinylhydrazone derivatives Acta Poloniae Pharmaceutica 66(5): 523-534Dorneanu, M.; Stefănescu, E.; Grosu, G. 1987: Synthesis of new pyridazine derivatives with biological activity Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 91(3): 541-543
Pluta, J.; Flendrich, M.; Cieplik, J. 1996: Synthesis and biological activity of some pyrimidine derivatives Bollettino Chimico Farmaceutico 135(8): 459-464
Singh, A.K.; Lohani, M.; Singh, U.P. 2011: Synthesis, characterization and biological activity of some 1, 3, 4-thiadiazol derivatives Pakistan Journal of Pharmaceutical Sciences 24(4): 571-574
Burak, K.; Machoń, Z. 1992: Synthesis of isothiazole derivatives with potential biological activity Die Pharmazie 47(7): 492-495
Witkiewicz, K.; Rykowski, Z.; Machoń, Z.; Lipnicka, U.; Burak, K. 1988: Synthesis of p-menthane derivatives with potential biological activity Die Pharmazie 43(2): 84-86
Cecchi, L.; Melani, F.; Filacchioni, G.; Tredici, M. 1984: Synthesis and biological activity of some 3-(pyrazol-1'-yl)indazole derivatives Il Farmaco; Edizione Scientifica 39(11): 945-952
Derry, W.B.; Pamidi, C.C.; Gupta, R.S. 1993: Synthesis and biological activity of novel thymidine derivatives of podophyllotoxin and 4'-demethylepipodophyllotoxin Anti-Cancer Drug Design 8(3): 203-221
El-Naggar, A.M.; Ahmed, F.S.; El-Salam, A.M.; El-Gazzar, M.A. 1982: Synthesis and biological activity of some new substituted aminoacyl-carbazole derivatives. Part Ii Il Farmaco; Edizione Scientifica 37(7): 494-500
Lyakhov, S.A.; Suveyzdis, Y.I.; Litvinova, L.A.; Andronati, S.A.; Rybalko, S.L.; Dyadyun, S.T. 2000: Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides Die Pharmazie 55(10): 733-736
Delgado, F.; Pastor, J.; García-Navío, J.L.; Vaquero, J.J.; Alvarez-Builla, J.; Sunkel, C.; de Casa-Juana, M.F.; Priego, J.G.; Santos, L.R.; Statkow, P.R.; Straumann, D. 1997: Nonpeptide angiotensin Ii receptor antagonists: synthesis and biological activity of 1H-imidazo and 1H-[1,2,3]-triazolo fused derivatives Farmaco 52(3): 147-155
Cavalleri, B.; Bellasio, E. 1970: Fluorinated organic compounds with potential biological activity. 8. Synthesis of beta-fluoro-beta-arylethylamine-N-derivatives Il Farmaco; Edizione Scientifica 25(12): 901-911
Rao, D.V.; Rao, V.V.R.; Raghunanda, P. 1985: Studies on embelin part iii. synthesis and biological activity of some anthranilic acid ester derivatives of embelin and embelin di o methyl ether Indian Journal of Chemistry. Sect. B 24(9): 988-991
Alunni Bistocchi, G.; De Meo, G.; Pedini, M.; Ricci, A.; Bastianini, L.; Sposini, T.; Sbaraglia, G.; Jacquignon, P. 1986: New heterocyclic derivatives of benzimidazole with germicidal activity. III. Synthesis and activity of derivatives of (formyl-5'-furyl-2')-2-benzimidazole with different substitutions at position 5 Il Farmaco; Edizione Scientifica 41(12): 970-983
Foks, H.; Janowiec, M. 1978: Pyrazine derivatives. XI. Synthesis and tuberculostatic activity of derivatives of pyrazineurea and pyrazinethiourea Acta Poloniae Pharmaceutica 35(5): 615-618
Pancechowska-Ksepko, D.; Foks, H.; Landowska, E.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XVII. Synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives Acta Poloniae Pharmaceutica 43(2): 116-123
Milczarska, B.; Foks, H.; Trapkowski, Z.; Milzyńska-Kołaczek, A.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1998: Studies on pyrazine derivatives. XXXII. Synthesis and tuberculostatic activity of acetylpyrazine thiosemicarbazone derivatives Acta Poloniae Pharmaceutica 55(4): 289-295
Milczarska, B.; Foks, H.; Sokołowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. 1999: Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives Acta Poloniae Pharmaceutica 56(2): 121-126
Brzezińska, E.; Stańczak, A.; Ochocki, Z. 2003: Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties Acta Poloniae Pharmaceutica 60(1): 15-20
Rudnicka, W.; Foks, H.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Studies of pyrazine derivatives. XXI. Synthesis and tuberculostatic activity of 4-aryl-1-pyrazinoylthiosemicarbazides and the products of their cyclization to 1,2,4-triazole-3-thione derivatives Acta Poloniae Pharmaceutica 43(6): 523-528