Synthesis of 2,4-disubstituted 5-aminopyrimidine-6-carboxylic acids derivatives part i
Machoń, Z.; Jasztold-Howorko, R.
Polish Journal of Pharmacology and Pharmacy 28(1): 61-67
1976
ISSN/ISBN: 0301-0244 PMID: 1264859 Document Number: 98070
5-Benzoyloaminoorotic acid in a reaction with POCl3 forms 2,4-dichloro-5-benzylo-aminopyrimidine-6-carboxylic acid lactam 3, which heated with aliphatic and aromatic amines gives corresponding amides 6-11. These compounds don't show any antiinflammatory or antivirus activity.
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