Synthesis of asymmetric 1,4-disubstituted piperazines and their psychotropic and cardiovascular actions. Part i
Korzycka, L.; Białasiewicz, W.; Szadowska, A.; Polakowski, P.; Graczyk, J.
Polish Journal of Pharmacology and Pharmacy 38(5-6): 535-543
1986
ISSN/ISBN: 0301-0244 PMID: 3575169 Document Number: 280812
New asymmetric piperazines 1-6 were obtained by condensation of 1-acylpiperazines with 1,2-epoxy-3-chloropropane, 1,2-epoxypropane, arylacid chlorides and secondary amines. The compounds displayed a biological activity: they depressed the central nervous system, altered the blood pressure, and one of them increased the coronary flow.
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