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Synthesis, physicochemical properties and biological activity of 2,6-disubstituted 7-methylpurines and the 7,9-dialkyl analogues

Kowalska, A.; Sochacka, J.

Acta Poloniae Pharmaceutica 60(2): 144-147

2003

ISSN/ISBN: 0001-6837
PMID: 13678326
Document Number: 559575
The preparation of several derivatives of 2,6-disubstituted-7-methylpurines and the 7,9-dialkyl analogues possessing a potential cytotoxic or cytostatic activity has been described. These compounds were tested for biological activity using a method for the determination of the toxic effects of chemical compounds on the growth of green alga Chlorella vulgaris, Beijerinck 1890. The effective concentration (EC50) was calculated.

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Di Braccio, M.; Roma, G.; Balbi, A.; Sottofattori, E.; Carazzone, M. 1989: Synthesis and preliminary pharmacological screening of 2,4-disubstituted N,N-dialkyl-1,8-naphthyridine-3-carboxamides Farmaco 44(9): 865-881
Katchalski-Katzir, E. 1996: Synthesis, physicochemical and biological properties of poly-alpha-amino acids--the simplest of protein models Acta Biochimica Polonica 43(1): 217-226
Gregán, F.; Durinda, J.; Tumová, I.; Polásek, E.; Borovanský, A. 1987: Preparation, physicochemical properties and biological activity of 1-(dimethylaminomethyl-cyclohexyl)-2-alkoxycarbanilates Ceskoslovenska Farmacie 36(10): 448-456
Pecorari, P.; Vampa, G.; Albasini, A.; Rinaldi, M.; Melegari, M.; Costi, M.P. 1988: Preparation and physicochemical properties of uracil derivatives with potential biological activity Il Farmaco; Edizione Scientifica 43(4): 311-318
Sansebastiano, L.; Mosti, L.; Menozzi, G.; Schenone, P.; Muratore, O.; Petta, A.; Debbia, E.; Schito, A.P.; Schito, G.C. 1993: Synthesis, antiviral (HSV-1) and antimycotic activities of ethyl or methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,4-disubstituted 5-pyrimidinecarboxylic acids and 2,4-disubstituted pyrimidines Farmaco 48(3): 335-355
Stankovicová, M.; Bachratá, M.; Blesová, M.; Bezáková, Z. 1992: Study of the relation between physico-chemical properties and the biological activity of basic heptacaine analogues Die Pharmazie 47(11): 874-875
Dmitrovskii, A.A.; Pozniakov, S.P. 1978: Synthesis of retinyl phosphate, its physico-chemical properties and biological activity Prikladnaia Biokhimiia i Mikrobiologiia 14(4): 558-564
Abbas, H.-A.S.; Al-Marhabi, A.R.M.; Ammar, Y.A. 2017: Design, Synthesis and Biological Evaluation of 2,3-Disubstituted and Fused Quinoxalines as Potential Anticancer and Antimicrobial Agents Acta Poloniae Pharmaceutica 74(2): 445-458
Abuzar, S.; Sharma, S.; Visen, P.K.; Gupta, S.; Katiyar, J.C. 1986: Synthesis and anthelmintic activity of 2,2'-disubstituted 5,5'-dibenzimidazolylsulfides and sulfones Arzneimittel-Forschung 36(3): 416-419
Vezin, J.C.; Mouzin, G.; Cousse, H.; Casadio, S. 1979: Nicafenine, a new analgesic. I. Synthesis and physicochemical properties Arzneimittel-Forschung 29(11): 1659-1661
Egwuagha, H.; Adegbolagun, O.M.; Emikpe, B.O.; Odeniyi, O.; Ogunremi, Y. 2015: Physicochemical properties and biological evaluation of Yoyo bitters African Journal of Medicine and Medical Sciences 44(2): 163-170
Smirnov, I.V.; Khachatur'ian, A.A.; Fetisova, L.V.; Ivanov, I.G.; Groznaia, T.G.; Smirnova, I.L.; Vorob'eva, T.M.; Akimova, T.A.; Iarochkin, V.S.; Rozenberg, G.I. 1992: The physicochemical and biological properties of the bovine hemoglobin polymer Gematologiia i Transfuziologiia 37(7-8): 15-17
Mcelhinney, R.S.; Mccormick, J.E.; Bibby, M.C.; Double, J.A.; Atassi, G.; Dumont, P.; Pratesi, G.; Radacic, M. 1989: Nucleoside analogues. 9. Seco-nucleoside analogues of some 5-fluorouracil/nitrosourea molecular combinations having uracil as base: synthesis and anti-tumour activity Anti-Cancer Drug Design 4(3): 191-207
Nagai, K.; Yokoyama, S.; Kawai, G.; Shuhadlnik, R.J.; Takaku, H. 1990: Synthesis and biological activities of 8-substituted 2-5A analogues Nucleic Acids Symposium Series 22: 13-14
Desai, N.C.; Undavia, N.K.; Trivedi, P.B.; Dave, D.; Vyas, G.D. 1998: Synthesis and anti-HIV activity of some non-nucleoside 2,3-disubstituted quinazoline derivatives (Part-V) Indian Journal of Experimental Biology 36(12): 1280-1283
Morimoto, T.; Fujisaki, Y.; Ito, Y.; Tanaka, Y. 1972: Biological and physicochemical properties of porcine parvovirus recovered from stillborn piglets National Institute of Animal Health Quarterly 12(3): 137-144
Jarosz, J. 1978: Polypeptide antibiotic 26a from Bacillus subtilis. III. Physicochemical and biological in vitro properties Acta Microbiologica Polonica 27(4): 359-374
Ozkanli, F.; Dalkara, S.; Calis, U.; Erol, K.; Ozdemir, M. 1993: Synthesis and anticholinergic activity of some new N,N-disubstituted carbamodithioic acid 2-oxo-2-(diphenylamino) ethyl esters Farmaco 48(8): 1153-1158
Abdel-Rahman, R.M.; Seada, M.; el-Gendy, Z.; Islam, I.E.; Mahmoud, M.B. 1993: Synthesis of some new 4,6-disubstituted-1,2,4-triazin-3,5(2H) diones and related compounds of potential antifungal activity Farmaco 48(3): 407-416
Obniska, J.; Zejc, A. 2003: Synthesis, physicochemical and anticonvulsant properties of some n-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione Acta Poloniae Pharmaceutica 60(5): 383-390