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The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4- (heterylamino) phenyl]piperazines

Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Lebedeva, M.N.; Kovalenko, F.P.; Dzhabarova, V.I.; Lychko, N.D.; Baiandina, D.G.; Naĭdenova, A.S.

Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 55-57

1991

ISSN/ISBN: 0025-8326
PMID: 1758368
Document Number: 4765
The synthesis and the acute toxicity and anticestodal activity of l-alkyl-4-[-(heterylamino)phenyl]-piperazines are presented. These compounds were found to be able to suppress the growth of larvocysts of Echinococcus multilocularis in cotton rats when injected intraperitoneally in a single dose of 0.25 g/kg, close to capacity of mebendazole. The tested compounds were also highly effective against the adult stage of Hymenolepis nana. Experimentally infected mice given an oral single dose of 0.2-0.5 g/kg of the drug were radically cured.

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The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines

Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Bolotina, L.A.; Lychko, N.D. 1990: The search for new antiparasitic agents. 1. the synthesis and study of the acute toxicity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
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