The search for new antiparasitic agents. 9. the anthelmintic activity of halogen-containing sulfonamidobenzamides
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Baiandina, D.G.; Kozyreva, N.P.; Lychko, N.D.; Bolotina, L.A.; Drusviatskaia, S.K.; Naĭdenova, A.S.
Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
1991
ISSN/ISBN: 0025-8326 PMID: 1818252 Document Number: 4766
The results of preclinical trials of 28 new compounds of haloid-containing sulfamidobenzamides with low toxicity are presented. The trials on a hymenolepiasis model showed that effectiveness of N-(2,5-dichlorophenyl)-2/(3-nitro-4-chlorophenyl) sulfonylamino/-5-bromobenzamide was similar to that of the well-known drug niclosamide. In the trials on an opisthorchiasis model, 2 compounds were shown to be highly effective, and on a trichocephaliasis model 5 compounds showed a high activity.
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