Research of antiparasitic agents: 1 (nitrophenyl) -3- (methyl-3-indolyl) -prop-2-ene-1-ones (Nitroindolylchalcones)
Alaoui, M.A.; Gayral, P.; Kirkiacharian, S.
Annales Pharmaceutiques Francaises 51(5): 260-265
1993
ISSN/ISBN: 0003-4509 PMID: 8154794 Document Number: 416359
The synthesis and the study of the antiparasitic properties of various 1-(nitro-phenyl)-3-(methyl-3-indolyl)-prop-2-ene-1-ones (Nitroindolylchalcones) show interesting antiprotozoal activities on E. histolytica and T. vaginalis. No significative activity appears in vivo with animals on helminthes.
Document emailed within 1 workday
Related Documents
Kirkiacharian, S.; Alaoui, M.A.; Ouidren, M.; Gayral, P. 1996: Synthesis and antiparasitic activity of new N-alkyl derivatives of 1-(nitrophenyl)-3-(methyl-3-indolyl)-prop-2-ene-1-ones (nitroindolylchalcones) Annales Pharmaceutiques Francaises 54(6): 272-275Jaffar, M.; Naylor, M.A.; Robertson, N.; Lockyer, S.D.; Phillips, R.M.; Everett, S.A.; Adams, G.E.; Stratford, I.J. 1998: 5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro Anti-Cancer Drug Design 13(2): 105-123
Horsmans, Y.; Larrey, D.; Pessayre, D.; Benhamou, J.P. 1990: Hepatotoxicity of antimicrobial agents. II: Urinary antiseptics, antitubercular agents, antiparasitic agents, antifungal agents, antiviral agents Gastroenterologie Clinique et Biologique 14(12): 919-924
Gemba, T.; Ninomiya, M.; Matsunaga, K.; Ueda, M. 1993: Effects of a novel calcium antagonist, S-(+)-methyl-4,7-dihydro-3-isobutyl-6- methyl-4-(3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate (S-312-d), on ischemic amino acid release and neuronal injury in stroke-prone spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 265(1): 463-467
Ueda, M.; Masui, M.; Kawakami, M.; Matsunaga, K.; Gemba, T.; Ninomiya, M.; Nakano, A.; Torii, M.; Adachi, I.; Ito, H. 1993: Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spontaneously hypertensive rats Arzneimittel-Forschung 43(12): 1291-1303
Nakajima, M.; Adachi, I.; Ueda, M. 1993: Pharmacological studies on a new Dihydrothienopyridine calcium antagonist. 2nd communication: effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4- (3-nitrophenyl)thieno[2,3-b]pyridine-5-carboxylate on the 1,4-dihydropyridine binding sites in the brain and on isolated arteries in the Cynomolgus monkey Arzneimittel-Forschung 43(12): 1276-1282
Kazda, S.; Garthoff, B.; Meyer, H.; Schlossmann, K.; Stoepel, K.; Towart, R.; Vater, W.; Wehinger, E. 1980: Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552) Arzneimittel-Forschung 30(12): 2144-2162
Kirchner, K.; Berge, H. 1975: Determination of methyl parathion (0.0-dimethyl-(p-nitrophenyl)-thiophosphoric acid ester) and metabolites in animal material and in feed Archiv für Experimentelle Veterinarmedizin 29(5): 643-647
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Baiandina, D.G.; Kozyreva, N.P.; Lychko, N.D.; Bolotina, L.A.; Drusviatskaia, S.K.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 9. the anthelmintic activity of halogen-containing sulfonamidobenzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Bolotina, L.A.; Lychko, N.D. 1990: The search for new antiparasitic agents. 1. the synthesis and study of the acute toxicity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Baiandina, D.G.; Dzhabarova, V.I.; Lychko, N.D.; Kozyreva, N.P.; Bolotina, L.A.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 7. a study of the relationship between the structure and the anthelmintic activity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 53-55
Péter, M.; Gyéresi, A.; Fülöp, F. 2001: Liquid chromatographic enantioseparation of beta-blocking agents with (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate as chiral derivatizing agent Journal of Chromatography A 910(2): 247-253
Takenaka, T.; Usuda, S.; Nomura, T.; Maeno, H.; Sado, T. 1976: Vasodilator profile of a new 1,4-dihydropyridine derivative, 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93) Arzneimittel-Forschung 26(12): 2172-2178
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Veretennikova, N.L.; Lebedeva, M.N.; Pereverzeva, E.V.; Lychko, N.D. 1995: The search for new antiparasitic agents. 14. the synthesis, acute toxicity and anthelmintic activity of N-(3,5-dibromobenzo-2,1,3-thiadiazolyl-4)-2-[(4-ch lorophenylsulfonyl)amino]-5-bromobenzamide Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 30-32
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Uvarova, N.A.; Lychko, N.D.; Drusviatskaia, S.K. 1991: The search for new antiparasitic agents. 6. the synthesis and study of the acute toxicity of halogenated benzamides containing benzophenone or diphenylsulfone substitutes at the nitrogen Meditsinskaia Parazitologiia i Parazitarnye Bolezni 4: 43-44
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Rabinovich, S.A.; Maksakovskaia, E.V.; Kulikovskaia, I.M.; Dadasheva, N.R.; Lebedeva, M.N.; Bekhli, A.F.; Lychko, N.D.; Uvarova, N.A. 1992: The search for new antiparasitic agents. 10. the synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine) Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1: 50-53
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Lychko, N.D.; Drusviatskaia, S.K.; Uvarova, N.A. 1991: The search for new antiparasitic agents. 3. the synthesis of haloid-containing sulfonamidobenzamides with a benzo-2,1,3-thiadiazole radical in the sulfonamide group and a study of their acute toxicity Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 36-38
Biniecki, S.; Horoszkiewicz, Z. 1974: Synthesis of indolyl-3-acetic acid (1-phenyl-2-3-dimethyl-5-oxo-4-pyrazolyl) amide of 3-indolylacetic acid and N-methyl-(1-phenyl-2,3-3-indolylacetic acid Acta Poloniae Pharmaceutica 31(2): 151-155
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Lebedeva, M.N.; Kovalenko, F.P.; Dzhabarova, V.I.; Lychko, N.D.; Baiandina, D.G.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 55-57
Melegari, M.; Raffa, L.; Vampa, G. 1970: Research in the field of 1,2-4-benzothiadiazine. XLVI. Action of methyl sulfates on 3-amino-1,2,4-benzothiadiazine-1,1-dioxide and on its N2-methyl derivative Il Farmaco; Edizione Scientifica 25(12): 953-960