The search for new antiparasitic agents. 3. the synthesis of haloid-containing sulfonamidobenzamides with a benzo-2,1,3-thiadiazole radical in the sulfonamide group and a study of their acute toxicity
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Lychko, N.D.; Drusviatskaia, S.K.; Uvarova, N.A.
Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 36-38
1991
ISSN/ISBN: 0025-8326 PMID: 2067493 Document Number: 4762
Sulfamidobenzamides containing benzo-2,1,3-thiadiazole ring in the sulfamide group were synthesized and examined for acute toxicity. All the compounds were shown to have low toxicity (when administered orally in a dose of 4 g/kg to mice), the above fact makes possible the search for agents with anthelminthic activity.
Document emailed within 1 workday
Related Documents
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Bolotina, L.A.; Lychko, N.D. 1990: The search for new antiparasitic agents. 1. the synthesis and study of the acute toxicity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Uvarova, N.A.; Lychko, N.D.; Drusviatskaia, S.K. 1991: The search for new antiparasitic agents. 6. the synthesis and study of the acute toxicity of halogenated benzamides containing benzophenone or diphenylsulfone substitutes at the nitrogen Meditsinskaia Parazitologiia i Parazitarnye Bolezni 4: 43-44
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Lebedeva, M.N.; Kovalenko, F.P.; Dzhabarova, V.I.; Lychko, N.D.; Baiandina, D.G.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 55-57
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Veretennikova, N.L.; Lebedeva, M.N.; Pereverzeva, E.V.; Lychko, N.D. 1995: The search for new antiparasitic agents. 14. the synthesis, acute toxicity and anthelmintic activity of N-(3,5-dibromobenzo-2,1,3-thiadiazolyl-4)-2-[(4-ch lorophenylsulfonyl)amino]-5-bromobenzamide Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 30-32
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Baiandina, D.G.; Kozyreva, N.P.; Lychko, N.D.; Bolotina, L.A.; Drusviatskaia, S.K.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 9. the anthelmintic activity of halogen-containing sulfonamidobenzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Rabinovich, S.A.; Maksakovskaia, E.V.; Kulikovskaia, I.M.; Dadasheva, N.R.; Lebedeva, M.N.; Bekhli, A.F.; Lychko, N.D.; Uvarova, N.A. 1992: The search for new antiparasitic agents. 10. the synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine) Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1: 50-53
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Baiandina, D.G.; Dzhabarova, V.I.; Lychko, N.D.; Kozyreva, N.P.; Bolotina, L.A.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 7. a study of the relationship between the structure and the anthelmintic activity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 53-55
Horsmans, Y.; Larrey, D.; Pessayre, D.; Benhamou, J.P. 1990: Hepatotoxicity of antimicrobial agents. II: Urinary antiseptics, antitubercular agents, antiparasitic agents, antifungal agents, antiviral agents Gastroenterologie Clinique et Biologique 14(12): 919-924
Loiseau, P.M.; Rekik, L.; Madaule, Y.; Gayral, P.; Wolf, J.G. 1993: Design, synthesis and biological study of new antiparasitic spiroarsoranes Arzneimittel-Forschung 43(9): 1004-1009
Zagnibeda, D.M.; Rudavskii, V.P. 1973: Synthesis of haloid acylamidophosphoric acids Farmatsevtychnyi Zhurnal 28(1): 32-34
Fujiwara, K.; Kohno, I.; Tanaka, K.; Ogita, S.; Sasaki, Y.; Hirabayashi, K.; Yakushiji, M.; Tsunematsu, R.; Terashima, Y.; Taguchi, T.; Ohashi, Y.; Noda, K. 1999: Phase Ii dose escalation: a novel approach to balancing efficacy and toxicity of anticancer agents. Japanese Docetaxel Ovarian Cancer Study Group Anticancer Research 19(1b): 639-644
Ilczuk, A. 1978: Search for anticholinergic agents. V. Synthesis and reactions of 5-chloro-2-phenyldioxane-1,3 Acta Poloniae Pharmaceutica 35(1): 1-6
Santagati, M.; Modica, M.; Santagati, A.; Russo, F.; Caruso, A.; Cutuli, V.; Di Pietro, E.; Amico-Roxas, M. 1994: Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4-thiadiazole derivatives Die Pharmazie 49(12): 880-884
Rajak, H.; Thakur, B.S.; Kumar, P.; Parmar, P.; Sharma, P.C.; Veerasamy, R.; Kharya, M.D. 2012: Synthesis and antiepileptic activity of some novel semicarbazones containing 1,3,4-thiadiazole and quinazoline ring Acta Poloniae Pharmaceutica 69(2): 253-261
Stutzman, L.; Glidewell, O. 1973: Multiple chemotherapeutic agents for Hodgkin disease. Comparison of three routines: a cooperative study by acute leukemia group B JAMA 225(10): 1202-1211
Nivière, P.; Didier, F.; Ernouf, G. 1973: Synthesis and study of pharmacodynamic properties of several benzo-gamma-pyronic amides halogenated in the nucleus Annales Pharmaceutiques Francaises 31(4): 313-320
Lushnikova, G.A. 1977: Toxicity and side effects of antibiotics in radiation sickness and during the use of aminothiol group radioprotective agents Antibiotiki 22(9): 825-829
Passarotti, C.M.; Valenti, M.; Marini, M. 1995: In the search for new antiinflammatory drugs: synthesis and antiinflammatory activity of some Thiazolo(3,2-a)pyrimidine derivatives containing a thioether group Bollettino Chimico Farmaceutico 134(11): 639-643
Foroumadi, A.; Soltani, F.; Rezaee, M.A.; Moshafi, M.H. 2003: Synthesis and evaluation of in vitro antimycobacterial activity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives Bollettino Chimico Farmaceutico 142(9): 416-419
Alcalde, E.; Maños, L.; Dinares, I.; Valls, N.; Elguero, J.; Escario, J.A.; Martinez, A.R.; Igea, A.; Osuna, A.; Ruiz-Perez, L.M. 1989: New derivatives of 5-nitroimidazole: synthesis and antiparasitic activity Farmaco 44(11): 1095-1107