The search for new antiparasitic agents. 10. the synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)

Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Rabinovich, S.A.; Maksakovskaia, E.V.; Kulikovskaia, I.M.; Dadasheva, N.R.; Lebedeva, M.N.; Bekhli, A.F.; Lychko, N.D.; Uvarova, N.A.; Mikhailitsyn, F.S; Kozyreva, N.P; Rabinovich, S.A; Maksakovskaia, E.V; Kulikovskaia, I.M; Dadasheva, N.R; Lebedeva, M.N; Bekhli, A.F; Lychko, N.D; Uvarova, N.A

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The search for new antiparasitic agents. 10. the synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4- (4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine)

Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Rabinovich, S.A.; Maksakovskaia, E.V.; Kulikovskaia, I.M.; Dadasheva, N.R.; Lebedeva, M.N.; Bekhli, A.F.; Lychko, N.D.; Uvarova, N.A.

Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1: 50-53

1992

ISSN/ISBN: 0025-8326

PMID: 1508078

Document Number: 4761

Synthesis is described and acute toxicity and antimalaria action is studied in new derivatives of quinoline and benzo(g)quinoline containing a 4-(4-alkylpiperazinyl-1)phenylamine substitute. Only the derivatives of benzo(g)quinoline were found to have a high antimalaria effect and to have advantages over the standard agent chloroquine on their tolerance and protective action. One of the compounds, 4-[4-(4-ethylpiperazinyl-1)phenylamino] benzo(g)quinoline, named QUINOPRAZINE, showed some action against Plasmodium berghei chloroquine--resistant infection (isolate LN-K65). This agent was elected for further tests.