Multiparameter analysis approach of antiparasitic structure-activity relationships in function of the parasite taxonomy
Lacroix, J.; Doré, J.C.; el Alami, J.; Reynouard, F.; Viel, C.; Lacroix, R.
Annales Pharmaceutiques Francaises 47(6): 383-393
1989
ISSN/ISBN: 0003-4509 PMID: 2488252 Document Number: 335467
In this paper the authors have studied the structure-parasitic activity relationships through the Chemical Abstracts data base which groups together the works published in this field for the last twenty years. With mathematical methods of multidimensional data reduction using a computer it has been possible to validate the classification of human parasites on the base of their sensitivity to chemical families. The specificity of the pharmacochemical relationships was described through two factorial maps. This work shows that it is possible to find new chemical series with potential parasitic activity.