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Structure-activity relationships in the effects of phenacemide analogs on serum creatinine and anticonvulsant activity

Richards, R.K.

Archives Internationales de Pharmacodynamie et de Therapie 244(1): 107-112

1980

ISSN/ISBN: 0003-9780
PMID: 7416882
Document Number: 166713
The anticonvulsant phenacemide had been shown to produce a marked rise of serum creatinine in humans and experimental animals without significant impairment of renal function. The mechanisms is not yet fully elucidated. A series of aromatic and aliphatic analogs of phenacemide were tested in rabbits under standardized conditions. A number of chemicals-structural requirements for this effect could be recognized within the limited number of compounds available. None of them exceeded the potency of phenacemide. There was no consistent correlation between the effect of serum creatinine and anticonvulsant potency in mice.

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Wang, S.Y.; Li, R.L.; Liu, W.Q.; Wang, G.Q.; Liu, P.; Song, J.M.; Pei, Y.Q.; Yao, H.Y.; Gao, X.M. 1986: Structure-anticonvulsant activity relationships of some cinnamamides of substituted aromatic ring Yao Xue Xue Bao 21(7): 542-545
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Mager, H.; Barth, A. 1979: Problems involved in the specification and interpretation of quantitative structure-activity relationships. Part 1: a modified type of structure-activity equations Die Pharmazie 34(9): 557-559
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Elferink, J.G.; Salemink, C.A. 1975: Relation between structure and cholinergic activity. II. Synthesis and muscarinic activity of some sulfur analogs of 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane-iodide Arzneimittel-Forschung 25(11): 1702-1705
Wang, E.H.; Du, F.D.; Xiang, B.R. 1981: Molecular connectivity studies on quantitative structure-activity of drugs. II. Quantitative structure-activity relationships for leucomycins, lincomycins and clindamycins Yao Xue Xue Bao 16(2): 86-91
Cechinel Filho, V.; Pinheiro, T.; Nunes, R.J.; Yunes, R.A.; Cruz, A.B.; Moretto, E. 1994: Antibacterial activity of N-phenylmaleimides, N-phenylsuccinimides and related compounds. Structure-activity relationships Farmaco 49(10): 675-677
Stanković, S. 2001: X-rays in molecular biophysics: structure-activity relationships and activity of steroid hormones Medicinski Pregled 54(9-10): 413-421
Gombar, V. 1986: Quantitative structure-activity relationships. Fujita-Ban analysis of beta-adrenergic blocking activity of 1-phenoxy-3-([(substituted amido)alkyl]amino)-2-propanols Arzneimittel-Forschung 36(7): 1014-1018
Tsapkina, E.N.; Gurskaia, G.V.; Zavgorodniĭ, S.G.; Lindeman, S.V.; Struchkov, I.T. 1988: The structure and antiviral activity of ribavirin analogs. II. Molecular and crystal structure of 1-(1,5-dihydroxy-3-oxapent-2-yl)-1,2,4-triazole-5-carboxamide Bioorganicheskaia Khimiia 14(8): 1092-1097
Lattrell, R.; Dürckheimer, W.; Kirrstetter, R.; Limbert, M.; Seibert, G. 1987: Structure-activity relationships in the cefpirome (HR 810) series: synthesis and antibacterial activity of 7 alpha-methoxy and 7 alpha-formylamino analogues of HR 810 Chemioterapia: international journal of the Mediterranean Society of Chemotherapy 6(2 Suppl): 96-97
Kuzuya, T. 1976: Structure and activity of insulin and its analogs Nihon Rinsho. Japanese Journal of Clinical Medicine 34(3): 632-638
Liu, W.Q.; Zhuo, J.C.; Lei, X.P. 1983: Chemical structure-anticonvulsant activity relationship in beta-substituted cinnamamides Yao Xue Xue Bao 18(12): 912-919
Jönsson, N.A. 1972: Chemical structure and teratogenic properties. 3. a review of available data on structure-activity relationships and mechanism of action of thalidomide analogues Acta Pharmaceutica Suecica 9(6): 521-542
Rogawski, M.A.; Yamaguchi, S.; Jones, S.M.; Rice, K.C.; Thurkauf, A.; Monn, J.A. 1991: Anticonvulsant activity of the low-affinity uncompetitive N-methyl-D- aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (ADCI): comparison with the structural analogs dizocilpine (MK-801) and carbamazepine Journal of Pharmacology and Experimental Therapeutics 259(1): 30-37
Reissmann, S.; Paegelow, I.; Arold, H. 1974: Connection between structure and biological activity of new bradykinin analogs Acta Biologica et Medica Germanica 33(1): 77-88
Saeki, T.; Ihara, M.; Fukuroda, T.; Yano, M. 1992: Structure-activity relationship for ETB agonism in truncated endothelin-1 analogs Biochemistry International 28(2): 305-312
Altomare, C.; Carotti, A.; Cellamare, S.; Carrieri, A.; Ciabatti, R.; Malabarba, A. 1994: Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships Journal of Pharmacy and Pharmacology 46(12): 994-999
Golubeva, M.G.; Kalishevskaia, T.M.; Solov'eva, M.E. 1992: Structure-activity determination of physiological reactions of vasopressin and its analogs on the hemostasis system Voprosy Meditsinskoi Khimii 38(1): 42-44
Rosenkranz, H.S.; Frierson, M.R.; Klopman, G. 1986: Use of structure-activity relationships in predicting carcinogenesis Iarc Scientific Publications 1986(83): 497-517