Relation between structure and cholinergic activity. II. Synthesis and muscarinic activity of some sulfur analogs of 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane-iodide
Elferink, J.G.; Salemink, C.A.
Arzneimittel-Forschung 25(11): 1702-1705
1975
ISSN/ISBN: 0004-4172 PMID: 1243076 Document Number: 83992
The synthesis of 2-methyl-5-trimethylammoniomethyl-1,3-oxathiolane and some homologs are described. The stereochemical aspects are discussed on the basis of the NMR-spectra. The muscarinic activity of the oxathiolane is compared with the activities of the corresponding dioxolane and dithiolane.
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