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Synthesis of new diheterocyclic derivatives of imidazole with antiparasitic activity

Quattara, L.; Debaert, M.; Cavier, R.

Il Farmaco; Edizione Scientifica 42(5): 383-396

1987

ISSN/ISBN: 0430-0920
PMID: 2886364
Document Number: 293223
A description is given of potential cyclic imidazoles such as 3,3-dichloro-2-methyleneimino-acrylonitrile derived from nitro or non-nitro heterocycles, as well as the hydrazone, semicarbazone and arylpropenone derivatives of the 4-chloro-2-(5-nitro-2-thienyl) (V), 5-imidazole carboxaldehyde (IV) and the 5-bromothienyl analogue. The antiparasitic activity was tested in vitro against Trichomonas vaginalis and Entamoeba histolytica. Some of the nitro containing compounds showed trichomonacidal activity whereas one of the non-nitro compounds with potential imidazole structure showed clear amebacidal activity. This compound, 3,3-dichloro-2-methyleneimino acrylonitrile has anti-ameba activity comparable with that of metronidazole.

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