Top Abstract Purchase Related
Home
>
Node
>
Subnode

Pyrrolnitrin analogues. IX. Synthesis and biological activity of 1-tolyl-3-nitrophenyl-5-methylpyrazole-4-carboxylic acids and 1-tolyl-3-methyl-5-nitrophenylpyrazole-4-carboxylic acids

Cecchi, L.; Melani, F.; Palazzino, G.; Filacchioni, G.; Porretta, G.C.

Il Farmaco; Edizione Scientifica 39(10): 888-900

1984

ISSN/ISBN: 0430-0920
PMID: 6510520
Document Number: 240766
The syntheses of all the possible 1-tolyl-3-nitrophenyl-5-methylpyrazole-4-carboxylic acids, 1-tolyl-3-methyl-5-nitrophenylprazole-4-carboxylic acids and of the corresponding carboxylates are reported. Several 1,3- and 1,5-diarylpyrazole derivatives were subjected to in vitro antibacterial screenings. Some acids showed activity against some strains of gram-positive bacteria. The results are discussed on the basis of structure-activity relationships.

Document emailed within 1 workday
Secure & encrypted payments

Filacchioni, G.; Nacci, V.; Stefancich, G.; Artico, M. 1974: Synthesis of pyrrolnitrin analogs. IV. 1-aryl-2-methyl-4-p-nitrophenylpyrrole-3-carboxylic acids Il Farmaco; Edizione Scientifica 29(11): 872-882
Massa, S.; Corelli, F.; Artico, M.; Mai, A.; Silvestri, R.; Pantaleoni, G.C.; Palumbo, G.; Fanini, D.; Giorgi, R. 1989: 5-Aroyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-carboxylic acids: synthesis and analgesic and neurobehavioral activity Farmaco 44(2): 109-123
Florvall, L.; Stjernström, N.E. 1979: 3-hydroxy-1,2,4-triazole analogues of biologically active carboxylic acids Acta Pharmaceutica Suecica 16(2): 81-88
Mikolajewska, H. 1974: Synthesis of 1,1-hexamethylene-2-hydrazides of some carboxylic acids Acta Poloniae Pharmaceutica 31(2): 181-188
Coudert, P.; Couquelet, J.; Fialip, J.; Sannajust, F.; Bastide, P.; Eschalier, A. 1987: Synthesis and pharmacologic evaluation of some dihydropyran carboxylic acids Il Farmaco; Edizione Scientifica 42(2): 145-158
Ponticelli, F.; Pagani, R.; Missale, M.C.; Leoncini, R.; Vannoni, D.; Marinello, E. 1983: Synthesis and NMR properties of 2-(4-pyridyl) thiazolidine-4-carboxylic acids Italian Journal of Biochemistry 32(2): 92-101
Foks, H.; Janowiec, M.; Sienicka, J. 1976: Studies on pyrazine derivatives. Part V. Synthesis and tuberculostatic activity of some 6-(beta-aminoethoxy)-pyrazine-2-carboxylic acids Polish Journal of Pharmacology and Pharmacy 28(3): 295-300
Machoń, Z.; Jasztold-Howorko, R. 1976: Synthesis of 2,4-disubstituted 5-aminopyrimidine-6-carboxylic acids derivatives part i Polish Journal of Pharmacology and Pharmacy 28(1): 61-67
Guo, H.Y.; Sun, L.Y.; Tang, Y.; Yan, G.H.; Zhang, Z.P. 1988: Studies on pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and antibacterial activity of 7-chloro-6-fluoro-1-ethyt-1, 4-dihydro-4-oxopyrido(2,3-c)pyridazine-3-carboxylic acid and derivatives Yao Xue Xue Bao 23(8): 566-573
Akhtar, M.; Sultana, N.; Arayne, M.S.; Siddiqi, T.A.; Khan, A. 2019: Synthesis, characterization, antimicrobial and enzyme inhibitory studies of moxifloxacin with aromatic carboxylic acids Pakistan Journal of Pharmaceutical Sciences 32(3): 1201-1206
Biliński, S.; Musik, I.; Urban, T. 1983: Reaction of 1-acyl-4-(p-tolyl)-thiosemicarbazide with alpha-halogenketones. I. 4-R-3-(p-tolyl)-thiazol-2-one hydrazone and 3-amino-4-R-2-(p-tolylimino)-4-thiazoline Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 38: 225-234
Lidina, P.V.; Mirskova, A.N.; Kichigina, E.L.; Shashnian, B.A.; Voronkov, M.G. 1979: Antibacterial and antiviral activity of the polychloroethyl- and beta,beta-dichlorovinylamides of carboxylic acids Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 7: 76-80
Cheng, C.Yan.; Mo, M.yun.; Grima, J.; Saso, L.; Tita, B.; Mruk, D.; Silvestrini, B. 2002: Indazole carboxylic acids in male contraception Contraception 65(4): 265-268
Biniecki, S.; Modrzejewska, W. 1977: Synthesis of 3-, 4-, 5- and 6-methyl-2-pyridylamides of furane-2-carboxylic acid Acta Poloniae Pharmaceutica 34(4): 341-343
Serova, L.I.; Korchagin, V.B. 1976: Chromatography of carboxylic acids on thin sorbent layers Antibiotiki 21(2): 182-185
Mitrokhin, S.D.; Ivanov, A.A. 1995: The significance of individual carboxylic acids in the feces in the diagnosis of dysbacteriosis Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 99-101
Markwardt, F.; Wagner, G.; Walsmann, P.; Horn, H.; Stürzebecher, J. 1972: Inhibition of trypsin and thrombin by amidinophenyl esters of aromatic carboxylic acids Acta Biologica et Medica Germanica 28(5): K19-K25
Hargitai, J.; Labádi, I.; Harri, L. 2000: Investigation of protonation and complex formation processes of some new polyamino carboxylic acids Acta Pharmaceutica Hungarica 70(3-6): 160-167
Zweerink, M.M.; Edison, A. 1986: Inhibition of Micrococcus luteus DNA gyrase by norfloxacin and 10 other quinolone carboxylic acids Antimicrobial Agents and Chemotherapy 29(4): 598-601
Chipens, G.I.; Afanasjeva, G.A.; Ancan, Y.E.; Zalitis, G.M.; Vegner, R.E.; Balodis, Y.Y. 1978: The antigen activity and structure of analogues and fragments of angiotensin, which contain enantiomeric forms of amino acids and aza-alpha'-homoamino acids Biokhimiia 43(5): 872-879