Synthesis and pharmacologic evaluation of some dihydropyran carboxylic acids
Coudert, P.; Couquelet, J.; Fialip, J.; Sannajust, F.; Bastide, P.; Eschalier, A.
Il Farmaco; Edizione Scientifica 42(2): 145-158
1987
ISSN/ISBN: 0430-0920 PMID: 3494631 Document Number: 300819
The synthesis of three new dihydropyran carboxylic acids has been performed by uncommon procedures: cyanosilylation, cyclisation of oxime. Their chemical structure was confirmed by I.R. and N.M.R. data. In a pharmacological evaluation they were found to possess significant effects on the passive cutaneous anaphylaxis test and on the central nervous system; one of them showed an interesting antiallergic effect whilst another showed and interesting sedative effect.