Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives
Lagorce, J.F.; Lakhdar, M.; Fatimi, J.; Nefaoui, S.; Raby, C.
Farmaco 47(12): 1477-1485
1992
ISSN/ISBN: 0014-827X PMID: 1294164 Document Number: 400594
A series of novel 2-pyridyl-2-thiobenzothiazole compounds was prepared and investigated by a number of in vitro methods in order to determine their anti-inflammatory properties. Results are discussed with reference to well known NSAIDs. (3-carboxy-2-pyridyl)-2-thiobenzothiazole had the most potent anti-inflammatory activity, being 1.34 times more active than indomethacin used as reference compound.
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