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N- (2-pyridinyl) -2-[2 (3H) -benzazolone-3-yl]acetamides: synthesis, antinociceptive and anti-inflammatory activity

Doğruer, D.S.; Unlü, S.; Yeşilada, E.; Fethi Sahin, M.

Farmaco 52(12): 745-750

1997

ISSN/ISBN: 0014-827X
PMID: 9648280
Document Number: 471861
Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis, IR and 1H NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and VII g, j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f, j, p showed statistically significant anti-inflammatory activity.

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