Synthesis and antitumor activity evaluation of 1-[ (arylidene) amino]adamantanes
Chimirri, A.; Gitto, R.; Grasso, S.; Monforte, A.M.; Zappalà, M.
Farmaco 49(10): 649-651
1994
ISSN/ISBN: 0014-827X PMID: 7826471 Document Number: 424185
Several 1-[(arylidene)amino]adamantanes were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell lines. Some of these derivatives showed specificity for human leukemia cell lines and 1-[(2-bromobenzylidene)amino]adamantane (2) (NSC 631076-L), the most active compound, was selected by the Biological Evaluation Committee (BEC), for in vivo testing.
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