Top Abstract Purchase Related
Home
>
Node
>
Subnode

Antitumor activity of a new amino acid derivative, N6,N9-bis- (butyloxycarbonylaminomethyl) -L-citrulline

Fujita, H.; Seto, Y.; Sakurai, T.; Ichimura, H.; Satoh, H.; Toyoshima, S.

Gan 69(1): 99-101

1978

ISSN/ISBN: 0016-450X
PMID: 205478
Document Number: 131495
Approximately 800 amino acid derivatives were synthesized and screened to evaluate their antitumor activity against various transplantable rat ascites hepatomas. Among them, N8,N9-bis(butyloxycarbonylaminomethyl)-L-citrulline (A-924) was highly effective against various rat ascites hepatomas. A-924, when given orally, exhibited prolongation of survival of rats implanted i.v. with ascites hepatoma cells such as AH-44, AH-66, AH-130, AH-66F or AH-41C.

Document emailed within 1 workday
Secure & encrypted payments

Callis, A.; Magnan de Bornier, B.; Serrano, J.J.; Bellet, H.; Saumade, R. 1991: Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man Arzneimittel-Forschung 41(6): 660-663
Fujita, H.; Sakurai, T.; Toyoshima, S. 1979: New antitumor amino acid derivative, A-748, evaluated in rat ascites hepatomas Cancer Treatment Reports 63(2): 223-224
Banner, R.J.; Charlson, A.J.; Gale, R.P.; Mcardle, N.T.; Trainor, K.E.; Watton, E.C. 1977: Antitumor activity of some amino acid metal systems Cancer Treatment Reports 61(3): 469-470
Fukushima, K.; Toyoshima, S. 1975: Antitumor activity of amino acid derivatives in the primary screening Gan 66(1): 29-36
Hibino, Y.; Kawarabayashi, Y.; Kuwahata, T.; Ueda, N.; Shinguu, H. 1991: Enhancement of 5-fluorouracil (5-FU) antitumor effect of amino acid solution (methionine deprived amino acid solution: AO-90) in 5-FU-resistant Yoshida sarcoma Gan to Kagaku Ryoho. Cancer and ChemoTherapy 18(6): 1055-1057
Tejeda, M.; Gaal, D.; Barna, K.; Csuka, O.; Kéri, G. 2003: The antitumor activity of the somatostatin structural derivative (TT-232) on different human tumor xenografts Anticancer Research 23(5a): 4061-4066
Posada, H.R. 1970: Clinical evaluation of a new derivative of 6-amino-penicillanic acid Revista Brasileira de Medicina 27(5): 279-285
Tanino, H.; Kubota, T.; Yamada, Y.; Koh, J.I.; Takeuchi, T.; Kase, S.; Furukawa, T.; Takahashi, M.; Fukuda, S.; Ogose, N. 1993: A newly developed hexamethylmelamine derivative, SAE9 with both antitumor and aromatase-inhibitory activity Anticancer Research 13(3): 623-626
Shirasaka, T.; Fujita, F.; Fujita, M.; Fukushima, M.; Taguchi, T.; Fujii, S. 1990: Antitumor activity and metabolism of BOF-A2, a new 5-fluorouracil derivative, with human cancers xenografted in nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 17(9): 1871-1876
Zhang, Y.J.; Wang, N.Q.; Liu, T.; Dong, Z.W. 1990: The antitumor activity of bovine serum albumin-mediated conjugate of hematoporphyrin derivative with antigastric cancer monoclonal antibody Yao Xue Xue Bao 25(12): 886-890
Chimirri, A.; Gitto, R.; Grasso, S.; Monforte, A.M.; Zappalà, M. 1994: Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes Farmaco 49(10): 649-651
Petrusewicz, J.; Siluk, D.; Kaliszan, R.; Foks, H.; Nowakowska, E. 1999: Comparative study of antithrombotic and antiaggregatory activity of acetylsalicylic acid, ticlopidine and a new noncarboxylic acid antiinflammatory pyrazine derivative HF90 Acta Poloniae Pharmaceutica 56(6): 463-467
Luks, H.J.; Spratt, T.E.; Vavrek, M.T.; Roland, S.F.; Weisburger, J.H. 1989: Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats Cancer Research 49(16): 4407-4411
Neil, G.L.; Berger, A.E.; McPartland, R.P.; Grindey, G.B.; Bloch, A. 1979: Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) Cancer Research 39(3): 852-856
Page, C.M.; Inglis, M.S.; Wheatley, D.N. 1982: The intracellular acid-extractable (acid-soluble) amino acid pool in mammalian cells: 4 An hypothesis to explain the effects of preloading on the exchange of amino acids across the cell membrane Cytobios 34(134): 105-123
Hadzija, O.; Keglević, D. 1977: Simple method for the separation of amino acids, amino sugars and amino alcohols related to the peptidoglycan components on a standard amino acid analyser Journal of Chromatography 138(2): 458-460
Iwaguchi, T.; Kitagawa, H.; Hirose, K.; Ishida, T.; Yamamoto, T. 1980: 5-Di-(2'-tetrahydropyranyl)secalonic acid D as a new antibiotic derivative with anticancer activity Gan 71(6): 900-906
Uccella, R.; Morenghi, R.; Agosti, C.; Saponati, G. 1983: Possible glucagon-mediated hypocholesterolemic activity of a nicotinic acid derivative (sorbinicate) Artery 11(5): 400-412
Rao, K.S.; Collard, M.P.; Cornet, J.; Trouet, A. 1989: Vinblastine-C4 alkyl maleoyl and amino acid maleoyl derivatives: III. Experimental antitumor activities of lactosaminated serum albumin conjugates Anticancer Research 9(4): 973-979
Grigorian, R.A.; Matevosova, K.S.; Karagian, A.T. 1984: Neuroactive amino acid content and the activity of enzymes of the gamma-aminobutyric acid system of the brain under the effect of Arzni mineral baths (experimental study) Voprosy Kurortologii Fizioterapii i Lechebnoi Fizicheskoi Kultury 3: 9-11