Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man
Callis, A.; Magnan de Bornier, B.; Serrano, J.J.; Bellet, H.; Saumade, R.
Arzneimittel-Forschung 41(6): 660-663
1991
ISSN/ISBN: 0004-4172 PMID: 1930358 Document Number: 383290
An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.