5-Di- (2'-tetrahydropyranyl) secalonic acid D as a new antibiotic derivative with anticancer activity
Iwaguchi, T.; Kitagawa, H.; Hirose, K.; Ishida, T.; Yamamoto, T.
Gan 71(6): 900-906
1980
ISSN/ISBN: 0016-450X PMID: 7274633 Document Number: 165456
A pyranyl derivative was chemically synthesized from secalonic acid D, an antibiotic obtained from culture filtrates of Penicillium oxalicum. Its anticancer activity towards highly antigenic rat bladder cancer cells, BC-47, implanted into inbred ACI/N rats was studied. The anticancer effect of the drug was similar to that of adriamycin. Delayed initiation of treatment, starting 5 days after the cancer implantation, was more effective than treatment starting from day 1. It was less effective in an immunodeficient host subsequently implanted with BC-47. This compound is thought to retard the cancer cell growth until the appearance of tumor immunity in the host.