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Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers

Arcamone, F.; Bernardi, L.; Giardino, P.; Patelli, B.; Marco, A.; Casazza, A.M.; Pratesi, G.; Reggiani, P.

Cancer Treatment Reports 60(7): 829-834

1976

ISSN/ISBN: 0361-5960
PMID: 1009518
Document Number: 108688
Four new derivatives of daunorubicin, characterized by the absence of the methoxyl group at the C-4 position, have been obtained by chemical synthesis. 4-Demethoxydaunorubicin (NSC-256439) was effective against L1210 and Gross leukemias and ascites and solid Sarcoma 180 at doses four to eight times lower than those effective for daunorubicin. The beta anomer of 4-demethoxydaunorubicin was active at doses 13and eight times higher than those of its corresponding alpha anomer against L1210 and Gross leukemias respectively. 4-Demethoxy-7,9-diepidaunorubicin and its beta anomer were devoid of any biologic activity at the doses tested.

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Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M. 1986: Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine Il Farmaco; Edizione Scientifica 41(9): 713-721
Li, S.W.; Sun, H.L.; Lu, X.J.; Zhang, S.Y.; Lu, F.L.; Dai, J.Y.; Xu, Y.B. 1981: Synthesis of cephalotaxine esters and their antitumor activity Yao Xue Xue Bao 16(11): 821-827
Mao, M.; Chen, Y.; Tian, X. 1998: Synthesis and antitumor activity of new heterocyclic 5-fluorouracil derivatives Yao Xue Xue Bao 33(5): 389-391
Abiko, T.; Sekino, H. 1987: The synthesis of peptides with potential thymic hormone activity: the synthesis of endo-Arg38a-deacetylthymosin beta 10 Biotechnology and Applied Biochemistry 9(1): 20-30
Luo, W.; Zhao, Y.-m.; Wang, Y.-x.; Xie, S.-q.; Zhao, J.; Wang, C.-j. 2007: Synthesis and antitumor activity of benzoic nitrogen mustard derivatives Yao Xue Xue Bao 42(12): 1327-1329
Pan, X-dao.; Liu, H-yan.; Sun, P-yang.; Zhu, C-gen.; Yang, J.; Yuan, K-hong.; Han, R. 2004: Synthesis and antitumor activity of 20-O-linked camptothecin ester derivatives Yao Xue Xue Bao 39(8): 591-597
Alunni-Bistocchi, G.; Orvietani, P.L.; Ricci, A.; Binaglia, L.; Orlando, M.; Orlando, P. 1990: Synthesis of 1-O-alkyl-2-O-methyl-glycerophospholipids with potential antitumor activity Farmaco 45(5): 499-509
Wang, B.; Pan, X.-d.; Liu, H.-y.; Yang, J.; Lü, Z.-y.; Zhao, J.-h. 2006: Synthesis and antitumor activity of nitrogen-based thiocolchicine derivatives Yao Xue Xue Bao 41(11): 1057-1063
Chimirri, A.; Gitto, R.; Grasso, S.; Monforte, A.M.; Zappalà, M. 1994: Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes Farmaco 49(10): 649-651
Huang, S.Q.; Jiang, Z.C.; Li, L.Z.; Xu, J.Y.; Yang, J. 1991: Study on porphyrins:synthesis and antitumor activity of porphyrin-fluorouracil compounds Yao Xue Xue Bao 26(6): 415-419
Ye, X-rong.; Chai, Y-hai.; Li, X-nan.; Wu, K-mei. 2004: Studies on the synthesis and antitumor activity of the derivatives of cephalotaxine alkaloid esters Yao Xue Xue Bao 39(6): 429-433
Cavalleri, B.; Bellasio, E. 1970: Fluorinated organic compounds with potential biological activity. 8. Synthesis of beta-fluoro-beta-arylethylamine-N-derivatives Il Farmaco; Edizione Scientifica 25(12): 901-911
Ozaki, S.; Nagase, T.; Ahmad, S.; Tamai, H.; Hoshi, A.; Iigo, M. 1987: Synthesis and antitumor activity of 1- or 3-(alpha-hetero substituted)alkyl-5-fluorouracil derivatives Nucleic Acids Symposium Series 18: 1-4
Ni, L.-l.; Yan, Q.; Wu, S.-m.; Xie, Y.-s.; Gao, L.-z.; Liu, Y.-j.; Huang, W.-l.; Hu, G.-q. 2015: Synthesis and antitumor activity of fluoroquinolon-3-yl-s-triazole sulfide ketones and their derivatives from ciprofloxacin Yao Xue Xue Bao 50(10): 1258-1262
Anderson, W.K.; Quagliato, D.A.; Haugwitz, R.D.; Narayanan, V.L.; Wolpert-DeFilippes, M.K. 1986: Synthesis, physical properties, and antitumor activity of tetraplatin and related tetrachloroplatinum(IV) stereoisomers of 1,2-diaminocyclohexane Cancer Treatment Reports 70(8): 997-1002
Mailliet, P.; Segal-Bendirdjian, E.; Kozelka, J.; Barreau, M.; Baudoin, B.; Bissery, M.C.; Gontier, S.; Laoui, A.; Lavelle, F.; Le Pecq, J.B. 1995: Asymmetrically substituted ethylenediamine platinum(II) complexes as antitumor agents: synthesis and structure-activity relationships Anti-Cancer Drug Design 10(1): 51-73
Varnavas, A.; Nisi, C.; Lassiani, L.; Sava, G.; Perissin, L.; Boccù, E. 1991: Synthesis and antitumor activity of hydrosoluble analogs of p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt Arzneimittel-Forschung 41(11): 1168-1172
Massa, S.; Stefancich, G.; Artico, M.; Corelli, F.; Silvestri, R. 1987: Potential antitumor agents. I. Synthesis of pyrroloindazole derivatives related to the pyrroloindole moieties of the antitumor antibiotic CC-1065 Il Farmaco; Edizione Scientifica 42(8): 567-574
Ouchi, T.; Banba, T.; Matsumoto, T.; Suzuki, S.; Suzuki, M. 1990: Synthesis and antitumor activity of conjugates of 5-fluorouracil and chito-oligosaccharides involving a hexamethylene spacer group and carbamoyl bonds Drug Design and Delivery 6(4): 281-287
Dawson, K.M. 1983: Activity of SC33428, a novel bishydrazone-bridged derivative of 4-demethoxydaunorubicin, against experimental tumors in mice Cancer Research 43(6): 2880-2883