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Quinoxaline chemistry. Part 8. 2-[Anilino]-3-[carboxy]-6 (7) -substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Loriga, M.; Moro, P.; Sanna, P.; Paglietti, G.; Zanetti, S.

Farmaco 52(8-9): 531-537

1997

ISSN/ISBN: 0014-827X
PMID: 9507661
Document Number: 481126
A total of 30 quinoxalines with a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumour panel cell lines between 10-5 and 10-4 molar concentrations. One single compound exhibited good activity against Candida albicans and another showed activity against HIV.

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