In vitro activity of voriconazole and three other antifungal agents against dermatophytes
Serrano-Martino, Mía.del.Carmen.; Chávez-Caballero, Mónica.; Valverde-Conde, A.; Claro, R.María.; Pemán, J.; Martín-Mazuelos, E.
Enfermedades Infecciosas Y Microbiologia Clinica 21(9): 484-487
2003
ISSN/ISBN: 0213-005X PMID: 14572380 Document Number: 561916
The in vitro activity of a new antifungal agent, voriconazole, was compared with three other antifungal agents, itraconazole, fluconazole and terbinafine, against 120 dermatophytes belonging to four species (61 Trichophyton mentagrophytes, 34 Microsporum canis, 13 M. gypseum and 12 T. rubrum). A broth microdilution method was used following the recommendations of the NCCLS document M38-P with some modifications. Terbinafine was the most active agent against the dermatophytes studied (minimum inhibitory concentration (MIC)90, <=0.03 micro g/ml), followed by voriconazole (MIC90, 0.25 micro g/ml) and itraconazole (MIC90, 0.5 micro g/ml). Fluconazole was the least active antifungal agent. The most susceptible species was M. canis. It is concluded that voriconazole is effective against dermatophytes.