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Design and biological evaluation of biphenyl-4-carboxylic acid hydrazide-hydrazone for antimicrobial activity

Deep, A.; Jain, S.; Sharma, P.C.; Verma, P.; Kumar, M.; Dora, C.P.

Acta Poloniae Pharmaceutica 67(3): 255-259

2010

ISSN/ISBN: 0001-6837
PMID: 20524427
Document Number: 639536
Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger All newly synthesized compounds exhibited promising results.

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