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Biological activity of new hydrazide and hydrazone derivatives with various substitutions

Piscopo, E.; Diurno, M.V.; Cirino, G.; Aliberti, F.

Bollettino della Societa Italiana di Biologia Sperimentale 59(3): 344-348

1983

ISSN/ISBN: 0037-8771
PMID: 9704133
Document Number: 205523
Fluorohydrazide derivatives of general formula (C) were tested for in vitro activity against Mycobacterium paratuberculosis ATCC 607. A group of 30 Rn-substituted hydrazone derivatives of general formula (D) and 5 hydrazone derivatives of general formula (E) were also prepared and tested for in vitro activity against gram-positive bacteria (Staphylococcus aureus, S. epidermidis, Bacillus subtilis, B. anthracis), gram-negative bacteria (Salmonella paratyphi A, S. paratyphi B, Escherichia coli, Brucella melitensis, Pseudomonas aeruginosa, Proteus mirabilis) and fungi (Candida albicans, Saccharomyces cerevisiae), by agar-diffusion method (Kirby-Bauer modified).

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