Antiviral activity of liposome-encapsulated cupric complex of isonicotinic acid hydrazide against avian myeloblastosis virus infection
Vasudevachari, M.B.; Antony, A.
Indian Journal of Experimental Biology 23(7): 393-396
1985
ISSN/ISBN: 0019-5189 PMID: 4077135 Document Number: 246289
Cupric complex of isonicotinic acid hydrazide (cupric-INH complex) inactivates avian myeloblastosis virus (AMV). The complex had no demonstrable chemotherapeutic activity against AMV infection in chicks. When encapsulated in positively charged liposomes the complex partial protected the chicks from AMV infection. The levels and stability of the complex in various tissues particularly in bone marrow, the target tissue for AMV multiplication, were higher in liposome-encapsulated cupric-INH complex injected chicks than in chicks injected with unencapsulated complex.